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Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease
Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin’ Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284764/ https://www.ncbi.nlm.nih.gov/pubmed/30574420 http://dx.doi.org/10.14336/AD.2018.0819 |
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author | Yu, Qiujin Guo, Peng Li, Danning Zuo, Lijun Lian, Tenghong Yu, Shuyang Hu, Yang Liu, Li Jin, Zhao Wang, Ruidan Piao, Yingshan Li, Lixia Wang, Xiaomin Zhang, Wei |
author_facet | Yu, Qiujin Guo, Peng Li, Danning Zuo, Lijun Lian, Tenghong Yu, Shuyang Hu, Yang Liu, Li Jin, Zhao Wang, Ruidan Piao, Yingshan Li, Lixia Wang, Xiaomin Zhang, Wei |
author_sort | Yu, Qiujin |
collection | PubMed |
description | Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin’ Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 healthy controls were consecutively recruited. Olfactory function was evaluated by self-report, HRS and Sniffin’ Sticks test. Patients were divided into AD with OD (AD-OD) and AD with no OD (AD-NOD) groups based on the results of the Sniffin’ Sticks test. Cognitive symptoms and neuropsychiatric symptoms were assessed by corresponding scales, and activities of daily living (ADL) were assessed by the ADL scale. In the control, MCI due to AD and AD dementia groups, the frequency of OD was 10.0%, 13.5% and 18.3%, respectively, by self-report; 6.7%, 24.3% and 48.3%, respectively, by HRS; and 3.3%, 13.5% and 65.0%, respectively, by the Sniffin’ Sticks test. Compared to the results of the Sniffin’ Sticks test, the diagnostic coincidence rates of OD by HRS in patients with MCI due to AD and AD dementia were 89.2% and 66.7%, respectively. Compared to the AD-NOD group, the scores of global cognition and memory, visuospatial ability and attention were all decreased (P<0.05), the apathy score was increased (P<0.05), and the ADL score was elevated (P<0.01). The frequency and accuracy of OD by self-report is relatively low. HRS can be used for screening olfaction in patients with MCI due to AD. The Sniffin’ Sticks test can be used for validating OD in AD patients. AD-OD patients have severe impairments in global cognition and multiple cognitive domains of memory, visuospatial ability and attention, as well as neuropsychiatric symptoms of apathy, and thus have seriously compromised ADL. |
format | Online Article Text |
id | pubmed-6284764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-62847642018-12-20 Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease Yu, Qiujin Guo, Peng Li, Danning Zuo, Lijun Lian, Tenghong Yu, Shuyang Hu, Yang Liu, Li Jin, Zhao Wang, Ruidan Piao, Yingshan Li, Lixia Wang, Xiaomin Zhang, Wei Aging Dis Orginal Article Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin’ Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 healthy controls were consecutively recruited. Olfactory function was evaluated by self-report, HRS and Sniffin’ Sticks test. Patients were divided into AD with OD (AD-OD) and AD with no OD (AD-NOD) groups based on the results of the Sniffin’ Sticks test. Cognitive symptoms and neuropsychiatric symptoms were assessed by corresponding scales, and activities of daily living (ADL) were assessed by the ADL scale. In the control, MCI due to AD and AD dementia groups, the frequency of OD was 10.0%, 13.5% and 18.3%, respectively, by self-report; 6.7%, 24.3% and 48.3%, respectively, by HRS; and 3.3%, 13.5% and 65.0%, respectively, by the Sniffin’ Sticks test. Compared to the results of the Sniffin’ Sticks test, the diagnostic coincidence rates of OD by HRS in patients with MCI due to AD and AD dementia were 89.2% and 66.7%, respectively. Compared to the AD-NOD group, the scores of global cognition and memory, visuospatial ability and attention were all decreased (P<0.05), the apathy score was increased (P<0.05), and the ADL score was elevated (P<0.01). The frequency and accuracy of OD by self-report is relatively low. HRS can be used for screening olfaction in patients with MCI due to AD. The Sniffin’ Sticks test can be used for validating OD in AD patients. AD-OD patients have severe impairments in global cognition and multiple cognitive domains of memory, visuospatial ability and attention, as well as neuropsychiatric symptoms of apathy, and thus have seriously compromised ADL. JKL International LLC 2018-12-04 /pmc/articles/PMC6284764/ /pubmed/30574420 http://dx.doi.org/10.14336/AD.2018.0819 Text en Copyright: © 2018 Qiujin et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Orginal Article Yu, Qiujin Guo, Peng Li, Danning Zuo, Lijun Lian, Tenghong Yu, Shuyang Hu, Yang Liu, Li Jin, Zhao Wang, Ruidan Piao, Yingshan Li, Lixia Wang, Xiaomin Zhang, Wei Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease |
title | Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease |
title_full | Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease |
title_fullStr | Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease |
title_full_unstemmed | Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease |
title_short | Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease |
title_sort | olfactory dysfunction and its relationship with clinical symptoms of alzheimer disease |
topic | Orginal Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284764/ https://www.ncbi.nlm.nih.gov/pubmed/30574420 http://dx.doi.org/10.14336/AD.2018.0819 |
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