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Interleukin-8 mRNA Expression in Locally Advanced Colorectal Cancer Patients

Purpose: Interleukin-8 (IL-8) has been proven to promote progression of malignant tumours and control angiogenesis processes. We aim to determine and compare interleukin-8 (IL-8) gene expression level in colorectal tumors (CCR) and peritumoral samples obtained through endoscopic biopsy. Material and...

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Detalles Bibliográficos
Autores principales: BĂRBĂLAN, A., STREAȚA, IOANA, IVAN, ELENA TATIANA, CHERCIU, IRINA, ȘURLIN, V., IOANA, M., SĂFTOIU, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284832/
https://www.ncbi.nlm.nih.gov/pubmed/30595877
http://dx.doi.org/10.12865/CHSJ.43.03.04
Descripción
Sumario:Purpose: Interleukin-8 (IL-8) has been proven to promote progression of malignant tumours and control angiogenesis processes. We aim to determine and compare interleukin-8 (IL-8) gene expression level in colorectal tumors (CCR) and peritumoral samples obtained through endoscopic biopsy. Material and methods: Total mRNA was obtained from both tumoral and peritumoral tissue samples collected from patients diagnosed with colorectal cancer. Through Quantitative Real Time PCR, IL-8 gene expression was assessed in both pathologic tissue and adjacent normal mucosa. Results: In our cohort, IL8 expression was higher in adjacent normal mucosa than in tumoral tissue, in all the samples. Further studies on larger groups are required to validate our results.