Exosomes—the enigmatic regulators of bone homeostasis

Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins,...

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Detalles Bibliográficos
Autores principales: Gao, Minhao, Gao, Weiyang, Papadimitriou, J. M., Zhang, Changqing, Gao, Junjie, Zheng, Minghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286319/
https://www.ncbi.nlm.nih.gov/pubmed/30534458
http://dx.doi.org/10.1038/s41413-018-0039-2
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author Gao, Minhao
Gao, Weiyang
Papadimitriou, J. M.
Zhang, Changqing
Gao, Junjie
Zheng, Minghao
author_facet Gao, Minhao
Gao, Weiyang
Papadimitriou, J. M.
Zhang, Changqing
Gao, Junjie
Zheng, Minghao
author_sort Gao, Minhao
collection PubMed
description Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.
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spelling pubmed-62863192018-12-10 Exosomes—the enigmatic regulators of bone homeostasis Gao, Minhao Gao, Weiyang Papadimitriou, J. M. Zhang, Changqing Gao, Junjie Zheng, Minghao Bone Res Review Article Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury. Nature Publishing Group UK 2018-12-07 /pmc/articles/PMC6286319/ /pubmed/30534458 http://dx.doi.org/10.1038/s41413-018-0039-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Gao, Minhao
Gao, Weiyang
Papadimitriou, J. M.
Zhang, Changqing
Gao, Junjie
Zheng, Minghao
Exosomes—the enigmatic regulators of bone homeostasis
title Exosomes—the enigmatic regulators of bone homeostasis
title_full Exosomes—the enigmatic regulators of bone homeostasis
title_fullStr Exosomes—the enigmatic regulators of bone homeostasis
title_full_unstemmed Exosomes—the enigmatic regulators of bone homeostasis
title_short Exosomes—the enigmatic regulators of bone homeostasis
title_sort exosomes—the enigmatic regulators of bone homeostasis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286319/
https://www.ncbi.nlm.nih.gov/pubmed/30534458
http://dx.doi.org/10.1038/s41413-018-0039-2
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