The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation

Heart failure is the most common cause of morbidity and hospitalization in the western civilization. Protein phosphatases play a key role in the basal cardiac contractility and in the responses to β-adrenergic stimulation with type-1 phosphatase (PP-1) being major contributor. We propose here that f...

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Detalles Bibliográficos
Autores principales: Singh, Simranjit, Lämmle, Simon, Giese, Heiko, Kämmerer, Susanne, Meyer-Roxlau, Stefanie, Alfar, Ezzaldin Ahmed, Dihazi, Hassan, Guan, Kaomei, El-Armouche, Ali, Richter, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286341/
https://www.ncbi.nlm.nih.gov/pubmed/30531830
http://dx.doi.org/10.1038/s41598-018-36267-6

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