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DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

Brain injury and inflammation induces a local release of extracellular vesicles (EVs) from astrocytes carrying proteins, RNAs, and microRNAs into the circulation. When these vesicles reach the liver, they stimulate the secretion of cytokines that mobilize peripheral immune cell infiltration into the...

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Detalles Bibliográficos
Autores principales:	Rojas, Camilo, Barnaeva, Elena, Thomas, Ajit G., Hu, Xin, Southall, Noel, Marugan, Juan, Chaudhuri, Amrita Datta, Yoo, Seung-Wan, Hin, Niyada, Stepanek, Ondrej, Wu, Ying, Zimmermann, Sarah C., Gadiano, Alexandra G., Tsukamoto, Takashi, Rais, Rana, Haughey, Norman, Ferrer, Marc, Slusher, Barbara S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286365/ https://www.ncbi.nlm.nih.gov/pubmed/30531925 http://dx.doi.org/10.1038/s41598-018-36144-2

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