Cargando…
Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1
During drug development, tissue samples serve as indicators of disease activity and pharmacodynamic responses. Reliable non-invasive measures of drug target engagement will facilitate identification of promising new treatments. Here we develop and validate a novel bi-transgenic mouse model of myoton...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286378/ https://www.ncbi.nlm.nih.gov/pubmed/30531949 http://dx.doi.org/10.1038/s41467-018-07517-y |