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Discovering de novo peptide substrates for enzymes using machine learning
The discovery of peptide substrates for enzymes with exclusive, selective activities is a central goal in chemical biology. In this paper, we develop a hybrid computational and biochemical method to rapidly optimize peptides for specific, orthogonal biochemical functions. The method is an iterative...
Autores principales: | Tallorin, Lorillee, Wang, JiaLei, Kim, Woojoo E., Sahu, Swagat, Kosa, Nicolas M., Yang, Pu, Thompson, Matthew, Gilson, Michael K., Frazier, Peter I., Burkart, Michael D., Gianneschi, Nathan C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286390/ https://www.ncbi.nlm.nih.gov/pubmed/30531862 http://dx.doi.org/10.1038/s41467-018-07717-6 |
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