Rapid disease progression in a patient with mismatch repair-deficient and cortisol secreting adrenocortical carcinoma treated with pembrolizumab

CONTEXT: Metastatic adrenocortical carcinoma (ACC) is an aggressive malignancy with a poor prognosis and limited therapeutic options. A subset of ACC is due to Lynch syndrome, an inherited tumor syndrome resulting from germline mutations in mismatch repair (MMR) genes. It has been demonstrated that...

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Detalles Bibliográficos
Autores principales: Casey, R.T., Giger, O., Seetho, I., Marker, A., Pitfield, D., Boyle, L.H., Gurnell, M., Shaw, A., Tischkowitz, M., Maher, E.R., Chatterjee, V.K., Janowitz, T., Mells, G., Corrie, P., Challis, B.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286406/
https://www.ncbi.nlm.nih.gov/pubmed/30262398
http://dx.doi.org/10.1053/j.seminoncol.2018.06.001

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