EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma

ABSTRACT: Epidermal growth factor receptor (EGFR) is a tyrosine kinase molecule associated to the initial stages of neoplastic transformation. High expression of EGFR is connected to aggressive tumor behavior and high risk of metastasis and treatment failure. The aim of our study was to analyze the...

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Detalles Bibliográficos
Autores principales: CERCELARU, LILIANA, STEPAN, A.E., MĂRGĂRITESCU, C, OSMAN, A, POPA, IONELIA-CARMEN, SIMIONESCU, CRISTIANA EUGENIA, MĂRGĂRITESCU, OTILIA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286452/
https://www.ncbi.nlm.nih.gov/pubmed/30595900
http://dx.doi.org/10.12865/CHSJ.43.04.09
Descripción
Sumario:ABSTRACT: Epidermal growth factor receptor (EGFR) is a tyrosine kinase molecule associated to the initial stages of neoplastic transformation. High expression of EGFR is connected to aggressive tumor behavior and high risk of metastasis and treatment failure. The aim of our study was to analyze the immunohistochemical expression of EGFR in 38 cases of laryngeal squamous cell carcinomas depending on clinicopathological parameters related to prognosis. The EGFR immunoreactions have statistical significant higher values in high grade carcinomas. Although the EGFR values were superior in advanced stages lesions, the aspect was not significant EGFR may be useful in identifying the aggressive laryngeal squamous carcinomas.

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