EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma

ABSTRACT: Epidermal growth factor receptor (EGFR) is a tyrosine kinase molecule associated to the initial stages of neoplastic transformation. High expression of EGFR is connected to aggressive tumor behavior and high risk of metastasis and treatment failure. The aim of our study was to analyze the...

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Autores principales: CERCELARU, LILIANA, STEPAN, A.E., MĂRGĂRITESCU, C, OSMAN, A, POPA, IONELIA-CARMEN, SIMIONESCU, CRISTIANA EUGENIA, MĂRGĂRITESCU, OTILIA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286452/
https://www.ncbi.nlm.nih.gov/pubmed/30595900
http://dx.doi.org/10.12865/CHSJ.43.04.09
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author CERCELARU, LILIANA
STEPAN, A.E.
MĂRGĂRITESCU, C
OSMAN, A
POPA, IONELIA-CARMEN
SIMIONESCU, CRISTIANA EUGENIA
MĂRGĂRITESCU, OTILIA
author_facet CERCELARU, LILIANA
STEPAN, A.E.
MĂRGĂRITESCU, C
OSMAN, A
POPA, IONELIA-CARMEN
SIMIONESCU, CRISTIANA EUGENIA
MĂRGĂRITESCU, OTILIA
author_sort CERCELARU, LILIANA
collection PubMed
description ABSTRACT: Epidermal growth factor receptor (EGFR) is a tyrosine kinase molecule associated to the initial stages of neoplastic transformation. High expression of EGFR is connected to aggressive tumor behavior and high risk of metastasis and treatment failure. The aim of our study was to analyze the immunohistochemical expression of EGFR in 38 cases of laryngeal squamous cell carcinomas depending on clinicopathological parameters related to prognosis. The EGFR immunoreactions have statistical significant higher values in high grade carcinomas. Although the EGFR values were superior in advanced stages lesions, the aspect was not significant EGFR may be useful in identifying the aggressive laryngeal squamous carcinomas.
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spelling pubmed-62864522018-12-28 EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma CERCELARU, LILIANA STEPAN, A.E. MĂRGĂRITESCU, C OSMAN, A POPA, IONELIA-CARMEN SIMIONESCU, CRISTIANA EUGENIA MĂRGĂRITESCU, OTILIA Curr Health Sci J Original Paper ABSTRACT: Epidermal growth factor receptor (EGFR) is a tyrosine kinase molecule associated to the initial stages of neoplastic transformation. High expression of EGFR is connected to aggressive tumor behavior and high risk of metastasis and treatment failure. The aim of our study was to analyze the immunohistochemical expression of EGFR in 38 cases of laryngeal squamous cell carcinomas depending on clinicopathological parameters related to prognosis. The EGFR immunoreactions have statistical significant higher values in high grade carcinomas. Although the EGFR values were superior in advanced stages lesions, the aspect was not significant EGFR may be useful in identifying the aggressive laryngeal squamous carcinomas. Medical University Publishing House Craiova 2017 2017-12-28 /pmc/articles/PMC6286452/ /pubmed/30595900 http://dx.doi.org/10.12865/CHSJ.43.04.09 Text en Copyright © 2018, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
CERCELARU, LILIANA
STEPAN, A.E.
MĂRGĂRITESCU, C
OSMAN, A
POPA, IONELIA-CARMEN
SIMIONESCU, CRISTIANA EUGENIA
MĂRGĂRITESCU, OTILIA
EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma
title EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_full EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_fullStr EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_full_unstemmed EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_short EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_sort egfr immunoexpression in laryngeal squamous cell carcinoma
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286452/
https://www.ncbi.nlm.nih.gov/pubmed/30595900
http://dx.doi.org/10.12865/CHSJ.43.04.09
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