Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line

ABSTRACT: Two novel 1,4-naphthoquinone derivatives containing salicylic acid and procaine moieties were synthesized and evaluated for their anticancer activity in vitro. The antiproliferative effect was assayed against MDA-MB-231 cells, a human breast adenocarcinoma cell line, using CellTiter-Glo® L...

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Detalles Bibliográficos
Autores principales: CREŢU, FLAVIA MARIA, STĂNOIU, B.P., PISOSCHI, CĂTĂLINA GABRIELA, PREDESCU, ANCA MIHAELA, RĂU, GABRIELA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286458/
https://www.ncbi.nlm.nih.gov/pubmed/30595899
http://dx.doi.org/10.12865/CHSJ.43.04.08
Descripción
Sumario:ABSTRACT: Two novel 1,4-naphthoquinone derivatives containing salicylic acid and procaine moieties were synthesized and evaluated for their anticancer activity in vitro. The antiproliferative effect was assayed against MDA-MB-231 cells, a human breast adenocarcinoma cell line, using CellTiter-Glo® Luminescent Cell Viability Assay. Both compounds tested proved a growth inhibition effect on this cell line in a dose-dependent manner. Our results showed that the compound with procaine effectively reduces breast cancer MDA-MB-231 cells viability and proliferation at higher concentration while that with salicylic acid had an inhibitory effect at lower concentrations and might be tested as an anticancer agent.

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