Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line

ABSTRACT: Two novel 1,4-naphthoquinone derivatives containing salicylic acid and procaine moieties were synthesized and evaluated for their anticancer activity in vitro. The antiproliferative effect was assayed against MDA-MB-231 cells, a human breast adenocarcinoma cell line, using CellTiter-Glo® L...

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Autores principales: CREŢU, FLAVIA MARIA, STĂNOIU, B.P., PISOSCHI, CĂTĂLINA GABRIELA, PREDESCU, ANCA MIHAELA, RĂU, GABRIELA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286458/
https://www.ncbi.nlm.nih.gov/pubmed/30595899
http://dx.doi.org/10.12865/CHSJ.43.04.08
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author CREŢU, FLAVIA MARIA
STĂNOIU, B.P.
PISOSCHI, CĂTĂLINA GABRIELA
PREDESCU, ANCA MIHAELA
RĂU, GABRIELA
author_facet CREŢU, FLAVIA MARIA
STĂNOIU, B.P.
PISOSCHI, CĂTĂLINA GABRIELA
PREDESCU, ANCA MIHAELA
RĂU, GABRIELA
author_sort CREŢU, FLAVIA MARIA
collection PubMed
description ABSTRACT: Two novel 1,4-naphthoquinone derivatives containing salicylic acid and procaine moieties were synthesized and evaluated for their anticancer activity in vitro. The antiproliferative effect was assayed against MDA-MB-231 cells, a human breast adenocarcinoma cell line, using CellTiter-Glo® Luminescent Cell Viability Assay. Both compounds tested proved a growth inhibition effect on this cell line in a dose-dependent manner. Our results showed that the compound with procaine effectively reduces breast cancer MDA-MB-231 cells viability and proliferation at higher concentration while that with salicylic acid had an inhibitory effect at lower concentrations and might be tested as an anticancer agent.
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spelling pubmed-62864582018-12-28 Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line CREŢU, FLAVIA MARIA STĂNOIU, B.P. PISOSCHI, CĂTĂLINA GABRIELA PREDESCU, ANCA MIHAELA RĂU, GABRIELA Curr Health Sci J Original Paper ABSTRACT: Two novel 1,4-naphthoquinone derivatives containing salicylic acid and procaine moieties were synthesized and evaluated for their anticancer activity in vitro. The antiproliferative effect was assayed against MDA-MB-231 cells, a human breast adenocarcinoma cell line, using CellTiter-Glo® Luminescent Cell Viability Assay. Both compounds tested proved a growth inhibition effect on this cell line in a dose-dependent manner. Our results showed that the compound with procaine effectively reduces breast cancer MDA-MB-231 cells viability and proliferation at higher concentration while that with salicylic acid had an inhibitory effect at lower concentrations and might be tested as an anticancer agent. Medical University Publishing House Craiova 2017 2017-12-28 /pmc/articles/PMC6286458/ /pubmed/30595899 http://dx.doi.org/10.12865/CHSJ.43.04.08 Text en Copyright © 2018, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
CREŢU, FLAVIA MARIA
STĂNOIU, B.P.
PISOSCHI, CĂTĂLINA GABRIELA
PREDESCU, ANCA MIHAELA
RĂU, GABRIELA
Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line
title Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line
title_full Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line
title_fullStr Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line
title_full_unstemmed Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line
title_short Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line
title_sort biological evaluation of two 1,4-naphthoquinone derivatives against a breast human adenocarcinoma cell line
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286458/
https://www.ncbi.nlm.nih.gov/pubmed/30595899
http://dx.doi.org/10.12865/CHSJ.43.04.08
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