P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma

ABSTRACT: p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell car...

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Detalles Bibliográficos
Autores principales: CERCELARU, LILIANA, STEPAN, A.E., MĂRGĂRITESCU, C, OSMAN, A., POPA, IONELIA-CARMEN, SIMIONESCU, CRISTIANA EUGENIA, MĂRGĂRITESCU, OTILIA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286461/
https://www.ncbi.nlm.nih.gov/pubmed/30595897
http://dx.doi.org/10.12865/CHSJ.43.04.06
Descripción
Sumario:ABSTRACT: p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell carcinomas and the relation with the clinicopathological aspects. We obtained variable p53 expression regarding the differentiation degree and tumor stage. The higher p53 immunotaining values were observed in high grade and advanced stages lesions. P53 may be useful in identifying aggresive laryngeal squamous carcinomas, a useful aspect for better stratification of patients for therapy.

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