P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma

ABSTRACT: p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell car...

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Autores principales: CERCELARU, LILIANA, STEPAN, A.E., MĂRGĂRITESCU, C, OSMAN, A., POPA, IONELIA-CARMEN, SIMIONESCU, CRISTIANA EUGENIA, MĂRGĂRITESCU, OTILIA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286461/
https://www.ncbi.nlm.nih.gov/pubmed/30595897
http://dx.doi.org/10.12865/CHSJ.43.04.06
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author CERCELARU, LILIANA
STEPAN, A.E.
MĂRGĂRITESCU, C
OSMAN, A.
POPA, IONELIA-CARMEN
SIMIONESCU, CRISTIANA EUGENIA
MĂRGĂRITESCU, OTILIA
author_facet CERCELARU, LILIANA
STEPAN, A.E.
MĂRGĂRITESCU, C
OSMAN, A.
POPA, IONELIA-CARMEN
SIMIONESCU, CRISTIANA EUGENIA
MĂRGĂRITESCU, OTILIA
author_sort CERCELARU, LILIANA
collection PubMed
description ABSTRACT: p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell carcinomas and the relation with the clinicopathological aspects. We obtained variable p53 expression regarding the differentiation degree and tumor stage. The higher p53 immunotaining values were observed in high grade and advanced stages lesions. P53 may be useful in identifying aggresive laryngeal squamous carcinomas, a useful aspect for better stratification of patients for therapy.
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spelling pubmed-62864612018-12-28 P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma CERCELARU, LILIANA STEPAN, A.E. MĂRGĂRITESCU, C OSMAN, A. POPA, IONELIA-CARMEN SIMIONESCU, CRISTIANA EUGENIA MĂRGĂRITESCU, OTILIA Curr Health Sci J Original Paper ABSTRACT: p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell carcinomas and the relation with the clinicopathological aspects. We obtained variable p53 expression regarding the differentiation degree and tumor stage. The higher p53 immunotaining values were observed in high grade and advanced stages lesions. P53 may be useful in identifying aggresive laryngeal squamous carcinomas, a useful aspect for better stratification of patients for therapy. Medical University Publishing House Craiova 2017 2017-12-28 /pmc/articles/PMC6286461/ /pubmed/30595897 http://dx.doi.org/10.12865/CHSJ.43.04.06 Text en Copyright © 2018, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
CERCELARU, LILIANA
STEPAN, A.E.
MĂRGĂRITESCU, C
OSMAN, A.
POPA, IONELIA-CARMEN
SIMIONESCU, CRISTIANA EUGENIA
MĂRGĂRITESCU, OTILIA
P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma
title P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_full P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_fullStr P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_full_unstemmed P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_short P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma
title_sort p53 immunoexpression in laryngeal squamous cell carcinoma
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286461/
https://www.ncbi.nlm.nih.gov/pubmed/30595897
http://dx.doi.org/10.12865/CHSJ.43.04.06
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