IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex

The recently discovered IFN‐λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN‐λ4 can inhibit HIV infection. Here, we show that IFN‐λ4 could suppress HIV infection of macrophages. This IFN‐λ4‐mediated HIV inhibition was compromised by the ant...

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Detalles Bibliográficos
Autores principales: Su, Qi‐Jian, Wang, Xu, Zhou, Run‐Hong, Guo, Le, Liu, Hang, Li, Jie‐Liang, Ho, Wen‐Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Experimental Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286684/
https://www.ncbi.nlm.nih.gov/pubmed/30247785
http://dx.doi.org/10.1111/sji.12717
Descripción
Sumario:The recently discovered IFN‐λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN‐λ4 can inhibit HIV infection. Here, we show that IFN‐λ4 could suppress HIV infection of macrophages. This IFN‐λ4‐mediated HIV inhibition was compromised by the antibodies against IFN‐λ receptor complex, IFN‐λR1/IL‐10R2. IFN‐λ4 enhanced the phosphorylation of STAT1, and induced antiviral interferon‐stimulated genes. These findings indicated that IFN‐λ4 can inhibit HIV via JAK/STAT signalling pathway.

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