IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex

The recently discovered IFN‐λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN‐λ4 can inhibit HIV infection. Here, we show that IFN‐λ4 could suppress HIV infection of macrophages. This IFN‐λ4‐mediated HIV inhibition was compromised by the ant...

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Autores principales: Su, Qi‐Jian, Wang, Xu, Zhou, Run‐Hong, Guo, Le, Liu, Hang, Li, Jie‐Liang, Ho, Wen‐Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Experimental Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286684/
https://www.ncbi.nlm.nih.gov/pubmed/30247785
http://dx.doi.org/10.1111/sji.12717
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author Su, Qi‐Jian
Wang, Xu
Zhou, Run‐Hong
Guo, Le
Liu, Hang
Li, Jie‐Liang
Ho, Wen‐Zhe
author_facet Su, Qi‐Jian
Wang, Xu
Zhou, Run‐Hong
Guo, Le
Liu, Hang
Li, Jie‐Liang
Ho, Wen‐Zhe
author_sort Su, Qi‐Jian
collection PubMed
description The recently discovered IFN‐λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN‐λ4 can inhibit HIV infection. Here, we show that IFN‐λ4 could suppress HIV infection of macrophages. This IFN‐λ4‐mediated HIV inhibition was compromised by the antibodies against IFN‐λ receptor complex, IFN‐λR1/IL‐10R2. IFN‐λ4 enhanced the phosphorylation of STAT1, and induced antiviral interferon‐stimulated genes. These findings indicated that IFN‐λ4 can inhibit HIV via JAK/STAT signalling pathway.
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spelling pubmed-62866842019-11-01 IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex Su, Qi‐Jian Wang, Xu Zhou, Run‐Hong Guo, Le Liu, Hang Li, Jie‐Liang Ho, Wen‐Zhe Scand J Immunol Experimental Immunology The recently discovered IFN‐λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN‐λ4 can inhibit HIV infection. Here, we show that IFN‐λ4 could suppress HIV infection of macrophages. This IFN‐λ4‐mediated HIV inhibition was compromised by the antibodies against IFN‐λ receptor complex, IFN‐λR1/IL‐10R2. IFN‐λ4 enhanced the phosphorylation of STAT1, and induced antiviral interferon‐stimulated genes. These findings indicated that IFN‐λ4 can inhibit HIV via JAK/STAT signalling pathway. John Wiley and Sons Inc. 2018-10-10 2018-11 /pmc/articles/PMC6286684/ /pubmed/30247785 http://dx.doi.org/10.1111/sji.12717 Text en © 2018 The Foundation for the Scandinavian Journal of Immunology This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
spellingShingle Experimental Immunology
Su, Qi‐Jian
Wang, Xu
Zhou, Run‐Hong
Guo, Le
Liu, Hang
Li, Jie‐Liang
Ho, Wen‐Zhe
IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex
title IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex
title_full IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex
title_fullStr IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex
title_full_unstemmed IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex
title_short IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex
title_sort ifn‐λ4 inhibits hiv infection of macrophages through signalling of ifn‐λr1/il‐10r2 receptor complex
topic Experimental Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286684/
https://www.ncbi.nlm.nih.gov/pubmed/30247785
http://dx.doi.org/10.1111/sji.12717
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