Drug Targeting of NR4A Nuclear Receptors for Treatment of Acute Myeloid Leukemia

NR4As are AML tumor suppressors that are frequently silenced in human AML. Despite their potential as novel targets for therapeutic intervention, mechanisms of NR4A silencing and strategies for their reactivation remain poorly defined. Here we show that NR4A silencing in AML occurs through blockade...

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Detalles Bibliográficos
Autores principales: Boudreaux, Seth P., Duren, Ryan P., Call, Steven G., Nguyen, Loc, Freire, Pablo R, Narayanan, Padmini, Redell, Michele S., Conneely, Orla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286710/
https://www.ncbi.nlm.nih.gov/pubmed/29884904
http://dx.doi.org/10.1038/s41375-018-0174-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286710/
https://www.ncbi.nlm.nih.gov/pubmed/29884904
http://dx.doi.org/10.1038/s41375-018-0174-1

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