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The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters

The cause of endometriosis remains unknown. However, studies investigating the link between this condition and the immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major immune checkpoint, programmed cell death protein 1 (PD-1) displays an important...

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Autores principales: Walankiewicz, Monika, Grywalska, Ewelina, Polak, Grzegorz, Korona-Glowniak, Izabela, Witt, Elzbieta, Surdacka, Agata, Kotarski, Jan, Rolinski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286737/
https://www.ncbi.nlm.nih.gov/pubmed/30595667
http://dx.doi.org/10.1155/2018/7041342
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author Walankiewicz, Monika
Grywalska, Ewelina
Polak, Grzegorz
Korona-Glowniak, Izabela
Witt, Elzbieta
Surdacka, Agata
Kotarski, Jan
Rolinski, Jacek
author_facet Walankiewicz, Monika
Grywalska, Ewelina
Polak, Grzegorz
Korona-Glowniak, Izabela
Witt, Elzbieta
Surdacka, Agata
Kotarski, Jan
Rolinski, Jacek
author_sort Walankiewicz, Monika
collection PubMed
description The cause of endometriosis remains unknown. However, studies investigating the link between this condition and the immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major immune checkpoint, programmed cell death protein 1 (PD-1) displays an important inhibitory function in the maintenance of peripheral tolerance. The expression of PD-1 and its ligand (PD-L1) may contribute to continuous T cell activation and development of inflammation and injury of the tissue. To our knowledge, this is the first study evaluating frequencies of PD-1-positive T CD3(+) cells (CD4(+) and CD8(+)) and B cells (CD19(+)) in patients with endometriosis. Peripheral blood (PB) samples from 25 female patients and 20 healthy age and sex-matched subjects serving as controls were used in the study. Using flow cytometric analysis, we assessed the differences in the frequencies of PD-1-positive T and B lymphocytes in the study group and healthy individuals. Alteration of the PD-1/PD-L1 axis may contribute to the pathogenesis of endometriosis, as patients with advanced disease are characterized by higher frequencies of PD-1-positive T and B cells. Expression of PD-1 and PD-L1 on T and B cells could represent the hallmark of immune system reaction to chronic antigenic exposition in patients with endometriosis.
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spelling pubmed-62867372018-12-30 The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters Walankiewicz, Monika Grywalska, Ewelina Polak, Grzegorz Korona-Glowniak, Izabela Witt, Elzbieta Surdacka, Agata Kotarski, Jan Rolinski, Jacek Mediators Inflamm Research Article The cause of endometriosis remains unknown. However, studies investigating the link between this condition and the immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major immune checkpoint, programmed cell death protein 1 (PD-1) displays an important inhibitory function in the maintenance of peripheral tolerance. The expression of PD-1 and its ligand (PD-L1) may contribute to continuous T cell activation and development of inflammation and injury of the tissue. To our knowledge, this is the first study evaluating frequencies of PD-1-positive T CD3(+) cells (CD4(+) and CD8(+)) and B cells (CD19(+)) in patients with endometriosis. Peripheral blood (PB) samples from 25 female patients and 20 healthy age and sex-matched subjects serving as controls were used in the study. Using flow cytometric analysis, we assessed the differences in the frequencies of PD-1-positive T and B lymphocytes in the study group and healthy individuals. Alteration of the PD-1/PD-L1 axis may contribute to the pathogenesis of endometriosis, as patients with advanced disease are characterized by higher frequencies of PD-1-positive T and B cells. Expression of PD-1 and PD-L1 on T and B cells could represent the hallmark of immune system reaction to chronic antigenic exposition in patients with endometriosis. Hindawi 2018-11-25 /pmc/articles/PMC6286737/ /pubmed/30595667 http://dx.doi.org/10.1155/2018/7041342 Text en Copyright © 2018 Monika Walankiewicz et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Walankiewicz, Monika
Grywalska, Ewelina
Polak, Grzegorz
Korona-Glowniak, Izabela
Witt, Elzbieta
Surdacka, Agata
Kotarski, Jan
Rolinski, Jacek
The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters
title The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters
title_full The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters
title_fullStr The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters
title_full_unstemmed The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters
title_short The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters
title_sort increase of circulating pd-1- and pd-l1-expressing lymphocytes in endometriosis: correlation with clinical and laboratory parameters
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286737/
https://www.ncbi.nlm.nih.gov/pubmed/30595667
http://dx.doi.org/10.1155/2018/7041342
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