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Folate-Functionalized Mesoporous Hollow SnO(2) Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

In this study, we prepared PTX-loaded mesoporous hollow SnO(2) nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DS...

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Detalles Bibliográficos
Autores principales: Lv, Huiling, Wu, Chao, Liu, Xuan, Bai, Andi, Cao, Yue, Shang, Wenjing, Hu, Lili, Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286759/
https://www.ncbi.nlm.nih.gov/pubmed/30596100
http://dx.doi.org/10.1155/2018/8526190
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author Lv, Huiling
Wu, Chao
Liu, Xuan
Bai, Andi
Cao, Yue
Shang, Wenjing
Hu, Lili
Liu, Ying
author_facet Lv, Huiling
Wu, Chao
Liu, Xuan
Bai, Andi
Cao, Yue
Shang, Wenjing
Hu, Lili
Liu, Ying
author_sort Lv, Huiling
collection PubMed
description In this study, we prepared PTX-loaded mesoporous hollow SnO(2) nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.
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spelling pubmed-62867592018-12-30 Folate-Functionalized Mesoporous Hollow SnO(2) Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy Lv, Huiling Wu, Chao Liu, Xuan Bai, Andi Cao, Yue Shang, Wenjing Hu, Lili Liu, Ying Biomed Res Int Research Article In this study, we prepared PTX-loaded mesoporous hollow SnO(2) nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier. Hindawi 2018-11-25 /pmc/articles/PMC6286759/ /pubmed/30596100 http://dx.doi.org/10.1155/2018/8526190 Text en Copyright © 2018 Huiling Lv et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lv, Huiling
Wu, Chao
Liu, Xuan
Bai, Andi
Cao, Yue
Shang, Wenjing
Hu, Lili
Liu, Ying
Folate-Functionalized Mesoporous Hollow SnO(2) Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy
title Folate-Functionalized Mesoporous Hollow SnO(2) Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy
title_full Folate-Functionalized Mesoporous Hollow SnO(2) Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy
title_fullStr Folate-Functionalized Mesoporous Hollow SnO(2) Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy
title_full_unstemmed Folate-Functionalized Mesoporous Hollow SnO(2) Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy
title_short Folate-Functionalized Mesoporous Hollow SnO(2) Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy
title_sort folate-functionalized mesoporous hollow sno(2) nanofibers as a targeting drug carrier to improve the antitumor effect of paclitaxel for liver cancer therapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286759/
https://www.ncbi.nlm.nih.gov/pubmed/30596100
http://dx.doi.org/10.1155/2018/8526190
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