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There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients
BACKGROUND: Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction, cardiovascular disease, and mortality. Several studies have separately analyzed endothelial function in these populations. However, data of patients with both CKD...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286770/ https://www.ncbi.nlm.nih.gov/pubmed/30596103 http://dx.doi.org/10.1155/2018/7926473 |
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author | Coutinho, Mariana Nogueira Carvalho, Aluizio Barbosa Dalboni, Maria Aparecida Mouro, Margaret Gori Higa, Elisa Mieko Suemitsu Costa-Hong, Valéria Bortolotto, Luiz Aparecido Figueiredo, Rejane Augusta de Oliveira Canziani, Maria Eugênia Fernandes |
author_facet | Coutinho, Mariana Nogueira Carvalho, Aluizio Barbosa Dalboni, Maria Aparecida Mouro, Margaret Gori Higa, Elisa Mieko Suemitsu Costa-Hong, Valéria Bortolotto, Luiz Aparecido Figueiredo, Rejane Augusta de Oliveira Canziani, Maria Eugênia Fernandes |
author_sort | Coutinho, Mariana Nogueira |
collection | PubMed |
description | BACKGROUND: Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction, cardiovascular disease, and mortality. Several studies have separately analyzed endothelial function in these populations. However, data of patients with both CKD and DM are scarce. The aim of this study was to evaluate whether the presence of DM has any additional effect on the endothelial dysfunction of CKD patients. METHODS: We measured endothelial progenitor cells (EPCs), stromal-derived factor 1 alpha (SDF-1α), serum and urinary nitric oxide (NO), flow-mediated dilation (FMD), and pulse wave velocity (PWV) in 37 CKD patients with DM (CKD-DM group) and in 37 without DM (CKD group). RESULTS: CKD-DM group had a higher prevalence of obesity (P < 0.01), previous myocardial infarction (P = 0.02), myocardial revascularization (P = 0.04), and a trend for more peripheral artery disease (P = 0.07). Additionally, CKD-DM group had higher EPC (P = 0.001) and PWV (P < 0.001) values. On the other hand, no difference in SDF-1α and serum or urinary NO and FMD was observed between the groups. CONCLUSIONS: Endothelial dysfunction is frequent in CKD patients, and an additive effect of diabetes cannot be implicated, suggesting the predominant role of uremia in this condition. |
format | Online Article Text |
id | pubmed-6286770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-62867702018-12-30 There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients Coutinho, Mariana Nogueira Carvalho, Aluizio Barbosa Dalboni, Maria Aparecida Mouro, Margaret Gori Higa, Elisa Mieko Suemitsu Costa-Hong, Valéria Bortolotto, Luiz Aparecido Figueiredo, Rejane Augusta de Oliveira Canziani, Maria Eugênia Fernandes J Diabetes Res Research Article BACKGROUND: Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction, cardiovascular disease, and mortality. Several studies have separately analyzed endothelial function in these populations. However, data of patients with both CKD and DM are scarce. The aim of this study was to evaluate whether the presence of DM has any additional effect on the endothelial dysfunction of CKD patients. METHODS: We measured endothelial progenitor cells (EPCs), stromal-derived factor 1 alpha (SDF-1α), serum and urinary nitric oxide (NO), flow-mediated dilation (FMD), and pulse wave velocity (PWV) in 37 CKD patients with DM (CKD-DM group) and in 37 without DM (CKD group). RESULTS: CKD-DM group had a higher prevalence of obesity (P < 0.01), previous myocardial infarction (P = 0.02), myocardial revascularization (P = 0.04), and a trend for more peripheral artery disease (P = 0.07). Additionally, CKD-DM group had higher EPC (P = 0.001) and PWV (P < 0.001) values. On the other hand, no difference in SDF-1α and serum or urinary NO and FMD was observed between the groups. CONCLUSIONS: Endothelial dysfunction is frequent in CKD patients, and an additive effect of diabetes cannot be implicated, suggesting the predominant role of uremia in this condition. Hindawi 2018-11-25 /pmc/articles/PMC6286770/ /pubmed/30596103 http://dx.doi.org/10.1155/2018/7926473 Text en Copyright © 2018 Mariana Nogueira Coutinho et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Coutinho, Mariana Nogueira Carvalho, Aluizio Barbosa Dalboni, Maria Aparecida Mouro, Margaret Gori Higa, Elisa Mieko Suemitsu Costa-Hong, Valéria Bortolotto, Luiz Aparecido Figueiredo, Rejane Augusta de Oliveira Canziani, Maria Eugênia Fernandes There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients |
title | There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients |
title_full | There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients |
title_fullStr | There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients |
title_full_unstemmed | There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients |
title_short | There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients |
title_sort | there is no impact of diabetes on the endothelial function of chronic kidney disease patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286770/ https://www.ncbi.nlm.nih.gov/pubmed/30596103 http://dx.doi.org/10.1155/2018/7926473 |
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