EGFR-Targeted Immunotoxin Exerts Antitumor Effects on Esophageal Cancers by Increasing ROS Accumulation and Inducing Apoptosis via Inhibition of the Nrf2-Keap1 Pathway

Previously, we developed a novel EGFR-targeted antibody (denoted as Pan), which has superior antitumor activity against EGFR-overexpressed tumors. However, it shows marginal effect on the growth of esophageal cancers. Therefore, the variable region of Pan was fused to a fragment of Pseudomonas exoto...

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Detalles Bibliográficos
Autores principales: Yang, Yun, Tian, Ziyin, Ding, Yanke, Li, Xiaojing, Zhang, Ziheng, Yang, Liu, Zhao, Fangyu, Ren, Feng, Guo, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286775/
https://www.ncbi.nlm.nih.gov/pubmed/30596104
http://dx.doi.org/10.1155/2018/1090287

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