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Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients

Chromobox (CBX) proteins are important components of epigenetic regulation complexes known to play key roles in hepatocellular carcinoma (HCC). Little is known about the function of distinct CBXs in HCC. To address this issue, the study investigated the roles of CBXs in the prognosis of HCC using ON...

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Autores principales: Ning, Gang, Huang, Yan-Lin, Zhen, Li-Min, Xu, Wen-Xiong, Jiao, Qian, Yang, Fang-Ji, Wu, Li-Na, Zheng, Yong-Yuan, Song, Jie, Wang, Yen-Sheng, Xie, Chan, Peng, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286817/
https://www.ncbi.nlm.nih.gov/pubmed/30481161
http://dx.doi.org/10.18632/aging.101658
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author Ning, Gang
Huang, Yan-Lin
Zhen, Li-Min
Xu, Wen-Xiong
Jiao, Qian
Yang, Fang-Ji
Wu, Li-Na
Zheng, Yong-Yuan
Song, Jie
Wang, Yen-Sheng
Xie, Chan
Peng, Liang
author_facet Ning, Gang
Huang, Yan-Lin
Zhen, Li-Min
Xu, Wen-Xiong
Jiao, Qian
Yang, Fang-Ji
Wu, Li-Na
Zheng, Yong-Yuan
Song, Jie
Wang, Yen-Sheng
Xie, Chan
Peng, Liang
author_sort Ning, Gang
collection PubMed
description Chromobox (CBX) proteins are important components of epigenetic regulation complexes known to play key roles in hepatocellular carcinoma (HCC). Little is known about the function of distinct CBXs in HCC. To address this issue, the study investigated the roles of CBXs in the prognosis of HCC using ONCOMINE, UALCAN, Human Protein Atlas, Kaplan-Meier Plotter, c-BioPortal databases. Over expressions of 8 CBXs members were found to be significantly associated with clinical cancer stages and pathological tumor grades in HCC patients. Besides, higher mRNA expressions of CBX1/2/3/6/8 were found to be significantly associated with shorter overall survival (OS) in HCC patients, while higher mRNA expression of CBX7 was associated with favorable OS. Multivariate analysis also showed that high mRNA expressions of CBX1/2/3/6/8 were independent prognostic factors for shorter OS of HCC patients. Moreover, high mutation rate of CBXs (51%) was also observed in HCC patients, and genetic alteration in CBXs was associated with shorter OS and disease-free survival (DFS) in HCC patients. Taken together, these results indicated that CBX1/2/3/6/8 could be prognostic biomarkers for survivals of HCC patients.
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spelling pubmed-62868172018-12-17 Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients Ning, Gang Huang, Yan-Lin Zhen, Li-Min Xu, Wen-Xiong Jiao, Qian Yang, Fang-Ji Wu, Li-Na Zheng, Yong-Yuan Song, Jie Wang, Yen-Sheng Xie, Chan Peng, Liang Aging (Albany NY) Research Paper Chromobox (CBX) proteins are important components of epigenetic regulation complexes known to play key roles in hepatocellular carcinoma (HCC). Little is known about the function of distinct CBXs in HCC. To address this issue, the study investigated the roles of CBXs in the prognosis of HCC using ONCOMINE, UALCAN, Human Protein Atlas, Kaplan-Meier Plotter, c-BioPortal databases. Over expressions of 8 CBXs members were found to be significantly associated with clinical cancer stages and pathological tumor grades in HCC patients. Besides, higher mRNA expressions of CBX1/2/3/6/8 were found to be significantly associated with shorter overall survival (OS) in HCC patients, while higher mRNA expression of CBX7 was associated with favorable OS. Multivariate analysis also showed that high mRNA expressions of CBX1/2/3/6/8 were independent prognostic factors for shorter OS of HCC patients. Moreover, high mutation rate of CBXs (51%) was also observed in HCC patients, and genetic alteration in CBXs was associated with shorter OS and disease-free survival (DFS) in HCC patients. Taken together, these results indicated that CBX1/2/3/6/8 could be prognostic biomarkers for survivals of HCC patients. Impact Journals 2018-11-27 /pmc/articles/PMC6286817/ /pubmed/30481161 http://dx.doi.org/10.18632/aging.101658 Text en Copyright © 2018 Ning et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Ning, Gang
Huang, Yan-Lin
Zhen, Li-Min
Xu, Wen-Xiong
Jiao, Qian
Yang, Fang-Ji
Wu, Li-Na
Zheng, Yong-Yuan
Song, Jie
Wang, Yen-Sheng
Xie, Chan
Peng, Liang
Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients
title Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients
title_full Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients
title_fullStr Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients
title_full_unstemmed Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients
title_short Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients
title_sort transcriptional expressions of chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286817/
https://www.ncbi.nlm.nih.gov/pubmed/30481161
http://dx.doi.org/10.18632/aging.101658
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