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Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study

Familial longevity is characterized by beneficial metabolic phenotype in lipid metabolism and APOE genetic variation. Although effects of lipid metabolism and the genetic basis for human longevity remain largely unclear, the contribution of high-density lipoprotein cholesterol (HDL-C) and APOE ε2 al...

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Autores principales: Wang, Jian, Shi, Liwei, Zou, Yunfeng, Tang, Jiexia, Cai, Jiansheng, Wei, Yi, Qin, Jian, Zhang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286851/
https://www.ncbi.nlm.nih.gov/pubmed/30485248
http://dx.doi.org/10.18632/aging.101663
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author Wang, Jian
Shi, Liwei
Zou, Yunfeng
Tang, Jiexia
Cai, Jiansheng
Wei, Yi
Qin, Jian
Zhang, Zhiyong
author_facet Wang, Jian
Shi, Liwei
Zou, Yunfeng
Tang, Jiexia
Cai, Jiansheng
Wei, Yi
Qin, Jian
Zhang, Zhiyong
author_sort Wang, Jian
collection PubMed
description Familial longevity is characterized by beneficial metabolic phenotype in lipid metabolism and APOE genetic variation. Although effects of lipid metabolism and the genetic basis for human longevity remain largely unclear, the contribution of high-density lipoprotein cholesterol (HDL-C) and APOE ε2 allele has been repeatedly demonstrated. This study was designed to determine whether ApoE isoforms and HDL-C levels marked the familial longevity status in an offspring cohort with the age range of 20-89 years old and subsequently to explore the correlation between these two markers and the aging. In the Bama Aging Study (BAS), we recruited 312 offspring from longevity historical families and 298 controls from non-longevity historical families. Information on APOE genotype frequencies, lipid levels, and population characteristics were recorded. No evidence was found to support the association of APOE genotypes with HDL-C and age. HDL-C was significantly higher in longevity group (p < 0.0001). Scatter plot showed a moderately strong linear relationship between the HDL-C level and age in longevity group (r = 0.213, p < 0.001). We conclude that the variation of the APOE gene may not influence familial longevity status at a certain age but the moderate-high HDL-C level contributes to the familial longevity in Bama.
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spelling pubmed-62868512018-12-17 Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study Wang, Jian Shi, Liwei Zou, Yunfeng Tang, Jiexia Cai, Jiansheng Wei, Yi Qin, Jian Zhang, Zhiyong Aging (Albany NY) Research Paper Familial longevity is characterized by beneficial metabolic phenotype in lipid metabolism and APOE genetic variation. Although effects of lipid metabolism and the genetic basis for human longevity remain largely unclear, the contribution of high-density lipoprotein cholesterol (HDL-C) and APOE ε2 allele has been repeatedly demonstrated. This study was designed to determine whether ApoE isoforms and HDL-C levels marked the familial longevity status in an offspring cohort with the age range of 20-89 years old and subsequently to explore the correlation between these two markers and the aging. In the Bama Aging Study (BAS), we recruited 312 offspring from longevity historical families and 298 controls from non-longevity historical families. Information on APOE genotype frequencies, lipid levels, and population characteristics were recorded. No evidence was found to support the association of APOE genotypes with HDL-C and age. HDL-C was significantly higher in longevity group (p < 0.0001). Scatter plot showed a moderately strong linear relationship between the HDL-C level and age in longevity group (r = 0.213, p < 0.001). We conclude that the variation of the APOE gene may not influence familial longevity status at a certain age but the moderate-high HDL-C level contributes to the familial longevity in Bama. Impact Journals 2018-11-28 /pmc/articles/PMC6286851/ /pubmed/30485248 http://dx.doi.org/10.18632/aging.101663 Text en Copyright © 2018 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Wang, Jian
Shi, Liwei
Zou, Yunfeng
Tang, Jiexia
Cai, Jiansheng
Wei, Yi
Qin, Jian
Zhang, Zhiyong
Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study
title Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study
title_full Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study
title_fullStr Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study
title_full_unstemmed Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study
title_short Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study
title_sort positive association of familial longevity with the moderate-high hdl-c concentration in bama aging study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286851/
https://www.ncbi.nlm.nih.gov/pubmed/30485248
http://dx.doi.org/10.18632/aging.101663
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