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The senescent cell epigenome

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory cytokine release in cells, caused by a variety of stresses. Recent work has convincingly linked the accumulation of senescent cells in aged tissues to a decline in health and a limit of lifespan, primarily...

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Detalles Bibliográficos
Autores principales: Yang, Na, Sen, Payel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286853/
https://www.ncbi.nlm.nih.gov/pubmed/30391936
http://dx.doi.org/10.18632/aging.101617
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author Yang, Na
Sen, Payel
author_facet Yang, Na
Sen, Payel
author_sort Yang, Na
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description A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory cytokine release in cells, caused by a variety of stresses. Recent work has convincingly linked the accumulation of senescent cells in aged tissues to a decline in health and a limit of lifespan, primarily through "inflammaging". Importantly, interventions that clear senescent cells have achieved marked improvements in healthspan and lifespan in mice. A growing list of studies show that environmental stimuli can affect aging and longevity through conserved pathways which, in turn, modulate chromatin states. This review consolidates key findings of chromatin state changes in senescence including histone modifications, histone variants, DNA methylation and changes in three-dimensional genome organization. This information will facilitate the identification of mechanisms and discovery of potential epigenetic targets for therapeutic interventions in aging and age-related disease.
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spelling pubmed-62868532018-12-17 The senescent cell epigenome Yang, Na Sen, Payel Aging (Albany NY) Review A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory cytokine release in cells, caused by a variety of stresses. Recent work has convincingly linked the accumulation of senescent cells in aged tissues to a decline in health and a limit of lifespan, primarily through "inflammaging". Importantly, interventions that clear senescent cells have achieved marked improvements in healthspan and lifespan in mice. A growing list of studies show that environmental stimuli can affect aging and longevity through conserved pathways which, in turn, modulate chromatin states. This review consolidates key findings of chromatin state changes in senescence including histone modifications, histone variants, DNA methylation and changes in three-dimensional genome organization. This information will facilitate the identification of mechanisms and discovery of potential epigenetic targets for therapeutic interventions in aging and age-related disease. Impact Journals 2018-11-03 /pmc/articles/PMC6286853/ /pubmed/30391936 http://dx.doi.org/10.18632/aging.101617 Text en Copyright © 2018 Yang and Sen http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Yang, Na
Sen, Payel
The senescent cell epigenome
title The senescent cell epigenome
title_full The senescent cell epigenome
title_fullStr The senescent cell epigenome
title_full_unstemmed The senescent cell epigenome
title_short The senescent cell epigenome
title_sort senescent cell epigenome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286853/
https://www.ncbi.nlm.nih.gov/pubmed/30391936
http://dx.doi.org/10.18632/aging.101617
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