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Dioscin Inhibits Virulence Factors of Candida albicans
Candida albicans infections present a heavy burden upon public health, with only a few drugs available, while biofilms formed by C. albicans worsen this situation. Dioscin has antitumor, anti-inflammatory, and hepatoprotective effects, and this study was conducted to evaluate the effects of dioscin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287159/ https://www.ncbi.nlm.nih.gov/pubmed/30598996 http://dx.doi.org/10.1155/2018/4651726 |
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author | Yang, Longfei Liu, Xin Zhong, Lili Sui, Yujie Quan, Guihua Huang, Ying Wang, Fang Ma, Tonghui |
author_facet | Yang, Longfei Liu, Xin Zhong, Lili Sui, Yujie Quan, Guihua Huang, Ying Wang, Fang Ma, Tonghui |
author_sort | Yang, Longfei |
collection | PubMed |
description | Candida albicans infections present a heavy burden upon public health, with only a few drugs available, while biofilms formed by C. albicans worsen this situation. Dioscin has antitumor, anti-inflammatory, and hepatoprotective effects, and this study was conducted to evaluate the effects of dioscin on the biofilm formation and development, as well as other virulence factors of C. albicans such as morphological transition, adhesion, and extracellular secreted phospholipase. Our results showed dioscin inhibits these virulence factors and has low cytotoxicity against mammalian cells. Considering protective effects of dioscin against damage on liver and kidney, dioscin may be used as a potential candidate for antifungal development. |
format | Online Article Text |
id | pubmed-6287159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-62871592018-12-31 Dioscin Inhibits Virulence Factors of Candida albicans Yang, Longfei Liu, Xin Zhong, Lili Sui, Yujie Quan, Guihua Huang, Ying Wang, Fang Ma, Tonghui Biomed Res Int Research Article Candida albicans infections present a heavy burden upon public health, with only a few drugs available, while biofilms formed by C. albicans worsen this situation. Dioscin has antitumor, anti-inflammatory, and hepatoprotective effects, and this study was conducted to evaluate the effects of dioscin on the biofilm formation and development, as well as other virulence factors of C. albicans such as morphological transition, adhesion, and extracellular secreted phospholipase. Our results showed dioscin inhibits these virulence factors and has low cytotoxicity against mammalian cells. Considering protective effects of dioscin against damage on liver and kidney, dioscin may be used as a potential candidate for antifungal development. Hindawi 2018-11-26 /pmc/articles/PMC6287159/ /pubmed/30598996 http://dx.doi.org/10.1155/2018/4651726 Text en Copyright © 2018 Longfei Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Longfei Liu, Xin Zhong, Lili Sui, Yujie Quan, Guihua Huang, Ying Wang, Fang Ma, Tonghui Dioscin Inhibits Virulence Factors of Candida albicans |
title | Dioscin Inhibits Virulence Factors of Candida albicans |
title_full | Dioscin Inhibits Virulence Factors of Candida albicans |
title_fullStr | Dioscin Inhibits Virulence Factors of Candida albicans |
title_full_unstemmed | Dioscin Inhibits Virulence Factors of Candida albicans |
title_short | Dioscin Inhibits Virulence Factors of Candida albicans |
title_sort | dioscin inhibits virulence factors of candida albicans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287159/ https://www.ncbi.nlm.nih.gov/pubmed/30598996 http://dx.doi.org/10.1155/2018/4651726 |
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