Pharmaceutico-analytical study of Samaguna, Dwiguna and Shadguna Balijarita Rasa Sindura

INTRODUCTION: Rasa Sindura is a Kupipakva Rasayana which is very popular and is widely used in therapeutics till date. Therapeutic property of Rasa Sindura varies with proportion of Gandhaka added to Parada. AIMS AND OBJECTIVE: The present study was carried out to reevaluate and compare differences in the pharmaceutical analytical study of Rasa Sindura prepared with the changing proportion of Gandhaka. To prepare Samaguna (RS), Dwiguna (2RS) and Shadguna (6RS) Balijarita Rasa Sindura and to carry out X-ray diffraction study (XRD) and Fourier-Transform Infrared spectroscopy (FTIR) of the samples. MATERIAL AND METHODS: Samaguna, Dwiguna and Shadguna Balijarita Rasa Sindura were prepared as per classical reference and the samples were subjected to XRD and FTIR. RESULTS: The duration of trituration for the preparation of Samaguna, Dwiguna and Shadguna Kajjali was 70, 40 and 24 h respectively. The duration of heating was 16, 16 and 19 h respectively. Average percentage yield of RS, 2RS and 6RS was 54%, 34.44% and 11.35%, respectively XRD showed increased crystallinity of the samples. FTIR spectrum revealed the decrease of unsaturated carbon and exchangeable proton as the proportion of sulfur increased in the preparation. CONCLUSION: XRD and FTIR suggested better stability of the crystals of 6RS than 2RS and RS.