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Role of individual S4 segments in gating of Ca(v)3.1 T-type calcium channel by voltage
Contributions of voltage sensing S4 segments in domains I – IV of Ca(V)3.1 channel to channel activation were analyzed. Neutralization of the uppermost charge in individual S4 segments by exchange of arginine for cysteine was employed. Mutant channels with single exchange in domains I – IV, in two a...
Autores principales: | Jurkovicova-Tarabova, Bohumila, Mackova, Katarina, Moravcikova, Lucia, Karmazinova, Maria, Lacinova, Lubica |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287678/ https://www.ncbi.nlm.nih.gov/pubmed/30403912 http://dx.doi.org/10.1080/19336950.2018.1543520 |
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