Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations

Heterozygous mutations in GBA, the gene encoding the lysosomal enzyme glucosylceramidase beta/β-glucocerebrosidase, comprise the most common genetic risk factor for Parkinson disease (PD), but the mechanisms underlying this association remain unclear. Here, we show that in Gba(L444P/WT) knockin mice...

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Detalles Bibliográficos
Autores principales: Li, Hongyu, Ham, Ahrom, Ma, Thong Chi, Kuo, Sheng-Han, Kanter, Ellen, Kim, Donghoon, Ko, Han Seok, Quan, Yi, Sardi, Sergio Pablo, Li, Aiqun, Arancio, Ottavio, Kang, Un Jung, Sulzer, David, Tang, Guomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper - Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287702/
https://www.ncbi.nlm.nih.gov/pubmed/30160596
http://dx.doi.org/10.1080/15548627.2018.1509818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287702/
https://www.ncbi.nlm.nih.gov/pubmed/30160596
http://dx.doi.org/10.1080/15548627.2018.1509818

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