The role of CMV in glioblastoma and implications for immunotherapeutic strategies

Controversy surrounds the role of cytomegalovirus (CMV) in glioblastoma (GBM). However, several studies have shown that CMV nucleic acids and proteins are present within GBM tumor tissue. CMV has been implicated in GBM pathogenesis by affecting tumor stem cell factors, angiogenesis and immune pathwa...

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Autores principales: Rahman, Maryam, Dastmalchi, Farhad, Karachi, Aida, Mitchell, Duane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287786/
https://www.ncbi.nlm.nih.gov/pubmed/30546954
http://dx.doi.org/10.1080/2162402X.2018.1514921
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author Rahman, Maryam
Dastmalchi, Farhad
Karachi, Aida
Mitchell, Duane
author_facet Rahman, Maryam
Dastmalchi, Farhad
Karachi, Aida
Mitchell, Duane
author_sort Rahman, Maryam
collection PubMed
description Controversy surrounds the role of cytomegalovirus (CMV) in glioblastoma (GBM). However, several studies have shown that CMV nucleic acids and proteins are present within GBM tumor tissue. CMV has been implicated in GBM pathogenesis by affecting tumor stem cell factors, angiogenesis and immune pathways. Anti-viral therapy has not been found to definitively improve outcomes for patients with GBM. Several studies have leveraged CMV by targeting CMV antigens using ex-vivo expanded T cells or dendritic cell vaccines. The initial results from these studies are promising and larger studies are underway.
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spelling pubmed-62877862018-12-13 The role of CMV in glioblastoma and implications for immunotherapeutic strategies Rahman, Maryam Dastmalchi, Farhad Karachi, Aida Mitchell, Duane Oncoimmunology Review Controversy surrounds the role of cytomegalovirus (CMV) in glioblastoma (GBM). However, several studies have shown that CMV nucleic acids and proteins are present within GBM tumor tissue. CMV has been implicated in GBM pathogenesis by affecting tumor stem cell factors, angiogenesis and immune pathways. Anti-viral therapy has not been found to definitively improve outcomes for patients with GBM. Several studies have leveraged CMV by targeting CMV antigens using ex-vivo expanded T cells or dendritic cell vaccines. The initial results from these studies are promising and larger studies are underway. Taylor & Francis 2018-10-16 /pmc/articles/PMC6287786/ /pubmed/30546954 http://dx.doi.org/10.1080/2162402X.2018.1514921 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Rahman, Maryam
Dastmalchi, Farhad
Karachi, Aida
Mitchell, Duane
The role of CMV in glioblastoma and implications for immunotherapeutic strategies
title The role of CMV in glioblastoma and implications for immunotherapeutic strategies
title_full The role of CMV in glioblastoma and implications for immunotherapeutic strategies
title_fullStr The role of CMV in glioblastoma and implications for immunotherapeutic strategies
title_full_unstemmed The role of CMV in glioblastoma and implications for immunotherapeutic strategies
title_short The role of CMV in glioblastoma and implications for immunotherapeutic strategies
title_sort role of cmv in glioblastoma and implications for immunotherapeutic strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287786/
https://www.ncbi.nlm.nih.gov/pubmed/30546954
http://dx.doi.org/10.1080/2162402X.2018.1514921
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