Warming up the tumor microenvironment in order to enhance immunogenicity

We have recently demonstrated that intratumoral CpG-B vaccination enhances anti-tumor immunity and tumor regression in mice. We further show that the local delivery of TLR9 agonists converts the tolerogenic tumor microenvironment into an immunopermissive one, which may benefit current immunotherapeu...

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Detalles Bibliográficos
Autores principales: Humbert, Marion, Hugues, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287788/
https://www.ncbi.nlm.nih.gov/pubmed/30546946
http://dx.doi.org/10.1080/2162402X.2018.1510710
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author Humbert, Marion
Hugues, Stephanie
author_facet Humbert, Marion
Hugues, Stephanie
author_sort Humbert, Marion
collection PubMed
description We have recently demonstrated that intratumoral CpG-B vaccination enhances anti-tumor immunity and tumor regression in mice. We further show that the local delivery of TLR9 agonists converts the tolerogenic tumor microenvironment into an immunopermissive one, which may benefit current immunotherapeutic anticancer strategies by enhancing innate and adaptive tumor-associated immune cell responses.
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spelling pubmed-62877882018-12-13 Warming up the tumor microenvironment in order to enhance immunogenicity Humbert, Marion Hugues, Stephanie Oncoimmunology Author’s View We have recently demonstrated that intratumoral CpG-B vaccination enhances anti-tumor immunity and tumor regression in mice. We further show that the local delivery of TLR9 agonists converts the tolerogenic tumor microenvironment into an immunopermissive one, which may benefit current immunotherapeutic anticancer strategies by enhancing innate and adaptive tumor-associated immune cell responses. Taylor & Francis 2018-10-01 /pmc/articles/PMC6287788/ /pubmed/30546946 http://dx.doi.org/10.1080/2162402X.2018.1510710 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s View
Humbert, Marion
Hugues, Stephanie
Warming up the tumor microenvironment in order to enhance immunogenicity
title Warming up the tumor microenvironment in order to enhance immunogenicity
title_full Warming up the tumor microenvironment in order to enhance immunogenicity
title_fullStr Warming up the tumor microenvironment in order to enhance immunogenicity
title_full_unstemmed Warming up the tumor microenvironment in order to enhance immunogenicity
title_short Warming up the tumor microenvironment in order to enhance immunogenicity
title_sort warming up the tumor microenvironment in order to enhance immunogenicity
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287788/
https://www.ncbi.nlm.nih.gov/pubmed/30546946
http://dx.doi.org/10.1080/2162402X.2018.1510710
work_keys_str_mv AT humbertmarion warmingupthetumormicroenvironmentinordertoenhanceimmunogenicity
AT huguesstephanie warmingupthetumormicroenvironmentinordertoenhanceimmunogenicity

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