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Impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: Results from a Korean nationwide study
OBJECTIVES: Despite an obvious improvement in the treatment of coronary artery disease (CAD) and survival rate of patients with CAD during recent decades, diabetes mellitus (DM) is still considered a risk factor of adverse clinical outcomes in these patients. Therefore, we sought to evaluate the cli...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287858/ https://www.ncbi.nlm.nih.gov/pubmed/30532214 http://dx.doi.org/10.1371/journal.pone.0208746 |
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author | Yang, Yujin Park, Gyung-Min Han, Seungbong Kim, Yong-Giun Suh, Jon Park, Hyun Woo Won, Ki-Bum Ann, Soe Hee Kim, Shin-Jae Kim, Dae-Won Park, Mahn-Won Her, Sung Ho Lee, Sang-Gon |
author_facet | Yang, Yujin Park, Gyung-Min Han, Seungbong Kim, Yong-Giun Suh, Jon Park, Hyun Woo Won, Ki-Bum Ann, Soe Hee Kim, Shin-Jae Kim, Dae-Won Park, Mahn-Won Her, Sung Ho Lee, Sang-Gon |
author_sort | Yang, Yujin |
collection | PubMed |
description | OBJECTIVES: Despite an obvious improvement in the treatment of coronary artery disease (CAD) and survival rate of patients with CAD during recent decades, diabetes mellitus (DM) is still considered a risk factor of adverse clinical outcomes in these patients. Therefore, we sought to evaluate the clinical implications of DM in patients with CAD who underwent contemporary percutaneous coronary intervention (PCI). METHODS: Based on the National Health Insurance claims data in South Korea, patients aged 18 years or older who had undergone PCI for the diagnosis of CAD between 2011 and 2015 were analyzed. Patients were classified into the DM (n = 26,872) and non-DM (n = 54,243) groups. The primary endpoint was all-cause mortality, and it was compared between the two groups via a propensity score matching analysis. RESULTS: The study population was categorized as patients with angina (n = 49,228) or acute myocardial infarction (AMI, n = 31,887). The study population had a median follow-up of 2.1 years (interquartile range, 1.1–3.2). After the propensity score matching analysis, 8,157 and 4,266 pairs of patients with angina and AMI were identified, respectively. In the matched angina group, the incidence of all-cause death was significantly higher in patients with DM (adjusted hazard ratio [aHR]: 1.30; 95% confidence interval [CI]: 1.16–1.47; p<0.001) than in those without DM. Moreover, in the matched AMI group, the incidence of all-cause death was significantly higher in patients with DM (aHR: 1.35; 95% CI: 1.19–1.53; p<0.001) than in those without DM. CONCLUSIONS: In patients undergoing contemporary PCI in Korea, the presence of DM was associated with poorer clinical outcomes. |
format | Online Article Text |
id | pubmed-6287858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62878582018-12-28 Impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: Results from a Korean nationwide study Yang, Yujin Park, Gyung-Min Han, Seungbong Kim, Yong-Giun Suh, Jon Park, Hyun Woo Won, Ki-Bum Ann, Soe Hee Kim, Shin-Jae Kim, Dae-Won Park, Mahn-Won Her, Sung Ho Lee, Sang-Gon PLoS One Research Article OBJECTIVES: Despite an obvious improvement in the treatment of coronary artery disease (CAD) and survival rate of patients with CAD during recent decades, diabetes mellitus (DM) is still considered a risk factor of adverse clinical outcomes in these patients. Therefore, we sought to evaluate the clinical implications of DM in patients with CAD who underwent contemporary percutaneous coronary intervention (PCI). METHODS: Based on the National Health Insurance claims data in South Korea, patients aged 18 years or older who had undergone PCI for the diagnosis of CAD between 2011 and 2015 were analyzed. Patients were classified into the DM (n = 26,872) and non-DM (n = 54,243) groups. The primary endpoint was all-cause mortality, and it was compared between the two groups via a propensity score matching analysis. RESULTS: The study population was categorized as patients with angina (n = 49,228) or acute myocardial infarction (AMI, n = 31,887). The study population had a median follow-up of 2.1 years (interquartile range, 1.1–3.2). After the propensity score matching analysis, 8,157 and 4,266 pairs of patients with angina and AMI were identified, respectively. In the matched angina group, the incidence of all-cause death was significantly higher in patients with DM (adjusted hazard ratio [aHR]: 1.30; 95% confidence interval [CI]: 1.16–1.47; p<0.001) than in those without DM. Moreover, in the matched AMI group, the incidence of all-cause death was significantly higher in patients with DM (aHR: 1.35; 95% CI: 1.19–1.53; p<0.001) than in those without DM. CONCLUSIONS: In patients undergoing contemporary PCI in Korea, the presence of DM was associated with poorer clinical outcomes. Public Library of Science 2018-12-10 /pmc/articles/PMC6287858/ /pubmed/30532214 http://dx.doi.org/10.1371/journal.pone.0208746 Text en © 2018 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yang, Yujin Park, Gyung-Min Han, Seungbong Kim, Yong-Giun Suh, Jon Park, Hyun Woo Won, Ki-Bum Ann, Soe Hee Kim, Shin-Jae Kim, Dae-Won Park, Mahn-Won Her, Sung Ho Lee, Sang-Gon Impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: Results from a Korean nationwide study |
title | Impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: Results from a Korean nationwide study |
title_full | Impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: Results from a Korean nationwide study |
title_fullStr | Impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: Results from a Korean nationwide study |
title_full_unstemmed | Impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: Results from a Korean nationwide study |
title_short | Impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: Results from a Korean nationwide study |
title_sort | impact of diabetes mellitus in patients undergoing contemporary percutaneous coronary intervention: results from a korean nationwide study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287858/ https://www.ncbi.nlm.nih.gov/pubmed/30532214 http://dx.doi.org/10.1371/journal.pone.0208746 |
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