Nucleosome positions establish an extended mutation signature in melanoma

Ultraviolet (UV) light-induced mutations are unevenly distributed across skin cancer genomes, but the molecular mechanisms responsible for this heterogeneity are not fully understood. Here, we assessed how nucleosome structure impacts the positions of UV-induced mutations in human melanomas. Analysi...

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Detalles Bibliográficos
Autores principales: Brown, Alexander J., Mao, Peng, Smerdon, Michael J., Wyrick, John J., Roberts, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287878/
https://www.ncbi.nlm.nih.gov/pubmed/30485262
http://dx.doi.org/10.1371/journal.pgen.1007823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287878/
https://www.ncbi.nlm.nih.gov/pubmed/30485262
http://dx.doi.org/10.1371/journal.pgen.1007823

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