Preclinical testing of 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide: a potent protein kinase C-ι inhibitor as a potential prostate carcinoma therapeutic

Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma. Previous in-vitro studies have shown that 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide (ICA-1s), a PKC-ι specific inhib...

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Detalles Bibliográficos
Autores principales: Apostolatos, André H., Apostolatos, Christopher A., Ratnayake, Wishrawana S., Neuger, Anthony, Sansil, Samer, Bourgeois, Marie, Acevedo-Duncan, Mildred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Preclinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287896/
https://www.ncbi.nlm.nih.gov/pubmed/30204596
http://dx.doi.org/10.1097/CAD.0000000000000694

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