Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera

A 78-year-old man who had a 20-year history of polycythemia vera (PV) with a JAK2 V617F mutation presented with gradually progressive disturbance of consciousness. Hyper-intense lesions in the peri-lateral ventricular area and left cerebellar hemisphere were observed by T2-weighted and fluid-attenua...

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Autores principales: Kajikawa, Natsuki, Seki, Yoshimoto, Fujio, Takayuki, Okoshi, Yasushi, Hori, Mitsuo, Saito, Hitoaki, Iijima, Tatsuo, Kojima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287982/
https://www.ncbi.nlm.nih.gov/pubmed/29984752
http://dx.doi.org/10.2169/internalmedicine.1093-18
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author Kajikawa, Natsuki
Seki, Yoshimoto
Fujio, Takayuki
Okoshi, Yasushi
Hori, Mitsuo
Saito, Hitoaki
Iijima, Tatsuo
Kojima, Hiroshi
author_facet Kajikawa, Natsuki
Seki, Yoshimoto
Fujio, Takayuki
Okoshi, Yasushi
Hori, Mitsuo
Saito, Hitoaki
Iijima, Tatsuo
Kojima, Hiroshi
author_sort Kajikawa, Natsuki
collection PubMed
description A 78-year-old man who had a 20-year history of polycythemia vera (PV) with a JAK2 V617F mutation presented with gradually progressive disturbance of consciousness. Hyper-intense lesions in the peri-lateral ventricular area and left cerebellar hemisphere were observed by T2-weighted and fluid-attenuated inversion recovery magnetic resonance imaging. Cytologic and genetic analyses of the lymphoma cells obtained from his cerebrospinal fluid established the diagnosis of B-cell lymphoma. No lesions outside of the brain were recognized. Because of his poor general condition, he was not treated actively. A postmortem analysis revealed a JAK2 V617F mutation in the lymphoma cells, suggesting their origin was a PV clone.
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spelling pubmed-62879822018-12-11 Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera Kajikawa, Natsuki Seki, Yoshimoto Fujio, Takayuki Okoshi, Yasushi Hori, Mitsuo Saito, Hitoaki Iijima, Tatsuo Kojima, Hiroshi Intern Med Case Report A 78-year-old man who had a 20-year history of polycythemia vera (PV) with a JAK2 V617F mutation presented with gradually progressive disturbance of consciousness. Hyper-intense lesions in the peri-lateral ventricular area and left cerebellar hemisphere were observed by T2-weighted and fluid-attenuated inversion recovery magnetic resonance imaging. Cytologic and genetic analyses of the lymphoma cells obtained from his cerebrospinal fluid established the diagnosis of B-cell lymphoma. No lesions outside of the brain were recognized. Because of his poor general condition, he was not treated actively. A postmortem analysis revealed a JAK2 V617F mutation in the lymphoma cells, suggesting their origin was a PV clone. The Japanese Society of Internal Medicine 2018-07-06 2018-11-15 /pmc/articles/PMC6287982/ /pubmed/29984752 http://dx.doi.org/10.2169/internalmedicine.1093-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kajikawa, Natsuki
Seki, Yoshimoto
Fujio, Takayuki
Okoshi, Yasushi
Hori, Mitsuo
Saito, Hitoaki
Iijima, Tatsuo
Kojima, Hiroshi
Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera
title Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera
title_full Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera
title_fullStr Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera
title_full_unstemmed Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera
title_short Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera
title_sort central nervous system lymphoma harboring the jak2 v617f mutation that developed after a 20-year history of polycythemia vera
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287982/
https://www.ncbi.nlm.nih.gov/pubmed/29984752
http://dx.doi.org/10.2169/internalmedicine.1093-18
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