Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma

The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stom...

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Autores principales: Ishigaki, Sho, Masaoka, Tatsuhiro, Kameyama, Hisako, Kawaida, Miho, Kameyama, Kaori, Mori, Takehiko, Kanai, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287990/
https://www.ncbi.nlm.nih.gov/pubmed/30429434
http://dx.doi.org/10.2169/internalmedicine.0737-18
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author Ishigaki, Sho
Masaoka, Tatsuhiro
Kameyama, Hisako
Kawaida, Miho
Kameyama, Kaori
Mori, Takehiko
Kanai, Takanori
author_facet Ishigaki, Sho
Masaoka, Tatsuhiro
Kameyama, Hisako
Kawaida, Miho
Kameyama, Kaori
Mori, Takehiko
Kanai, Takanori
author_sort Ishigaki, Sho
collection PubMed
description The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma.
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spelling pubmed-62879902018-12-11 Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma Ishigaki, Sho Masaoka, Tatsuhiro Kameyama, Hisako Kawaida, Miho Kameyama, Kaori Mori, Takehiko Kanai, Takanori Intern Med Case Report The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma. The Japanese Society of Internal Medicine 2018-11-15 /pmc/articles/PMC6287990/ /pubmed/30429434 http://dx.doi.org/10.2169/internalmedicine.0737-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ishigaki, Sho
Masaoka, Tatsuhiro
Kameyama, Hisako
Kawaida, Miho
Kameyama, Kaori
Mori, Takehiko
Kanai, Takanori
Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma
title Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma
title_full Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma
title_fullStr Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma
title_full_unstemmed Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma
title_short Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma
title_sort methotrexate-associated lymphoproliferative disorder of the stomach presumed to be mucosa-associated lymphoid tissue lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287990/
https://www.ncbi.nlm.nih.gov/pubmed/30429434
http://dx.doi.org/10.2169/internalmedicine.0737-18
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