Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation

Mutations in the rpoB gene of Mycobacterium tuberculosis can result in resistance to rifampin. Among various mutations in the rpoB gene, some known as disputed rpoB mutations can cause low-level rifampin resistance. It has been suggested that a high-dose rifampin (20 mg/kg)-based regimen might be ef...

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Autores principales: Jeong, Dae Hyun, Kang, Ye Won, Kim, Jin Young, Han, Ji Soo, Jo, Kyung-Wook, Shim, Tae Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288001/
https://www.ncbi.nlm.nih.gov/pubmed/29984742
http://dx.doi.org/10.2169/internalmedicine.9571-17
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author Jeong, Dae Hyun
Kang, Ye Won
Kim, Jin Young
Han, Ji Soo
Jo, Kyung-Wook
Shim, Tae Sun
author_facet Jeong, Dae Hyun
Kang, Ye Won
Kim, Jin Young
Han, Ji Soo
Jo, Kyung-Wook
Shim, Tae Sun
author_sort Jeong, Dae Hyun
collection PubMed
description Mutations in the rpoB gene of Mycobacterium tuberculosis can result in resistance to rifampin. Among various mutations in the rpoB gene, some known as disputed rpoB mutations can cause low-level rifampin resistance. It has been suggested that a high-dose rifampin (20 mg/kg)-based regimen might be effective in treating tuberculosis (TB) caused by M. tuberculosis with disputed rpoB mutations exhibiting low-level resistance. We herein report the first two cases of pulmonary TB caused by M. tuberculosis with a disputed rpoB mutation (CTG511CCG) that showed successful treatment outcomes with a high-dose rifampin-based regimen.
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spelling pubmed-62880012018-12-11 Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation Jeong, Dae Hyun Kang, Ye Won Kim, Jin Young Han, Ji Soo Jo, Kyung-Wook Shim, Tae Sun Intern Med Case Report Mutations in the rpoB gene of Mycobacterium tuberculosis can result in resistance to rifampin. Among various mutations in the rpoB gene, some known as disputed rpoB mutations can cause low-level rifampin resistance. It has been suggested that a high-dose rifampin (20 mg/kg)-based regimen might be effective in treating tuberculosis (TB) caused by M. tuberculosis with disputed rpoB mutations exhibiting low-level resistance. We herein report the first two cases of pulmonary TB caused by M. tuberculosis with a disputed rpoB mutation (CTG511CCG) that showed successful treatment outcomes with a high-dose rifampin-based regimen. The Japanese Society of Internal Medicine 2018-07-06 2018-11-15 /pmc/articles/PMC6288001/ /pubmed/29984742 http://dx.doi.org/10.2169/internalmedicine.9571-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Jeong, Dae Hyun
Kang, Ye Won
Kim, Jin Young
Han, Ji Soo
Jo, Kyung-Wook
Shim, Tae Sun
Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation
title Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation
title_full Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation
title_fullStr Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation
title_full_unstemmed Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation
title_short Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation
title_sort successful treatment with a high-dose rifampin-containing regimen for pulmonary tuberculosis with a disputed rpob mutation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288001/
https://www.ncbi.nlm.nih.gov/pubmed/29984742
http://dx.doi.org/10.2169/internalmedicine.9571-17
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