From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?

First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. Vasn KO mice die after 3 weeks of life from unknown cause(s). No human disease has bee...

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Autores principales: Bonnet, Anne-Laure, Chaussain, Catherine, Broutin, Isabelle, Rochefort, Gaël Y., Schrewe, Heinrich, Gaucher, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288187/
https://www.ncbi.nlm.nih.gov/pubmed/30564578
http://dx.doi.org/10.3389/fmed.2018.00335
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author Bonnet, Anne-Laure
Chaussain, Catherine
Broutin, Isabelle
Rochefort, Gaël Y.
Schrewe, Heinrich
Gaucher, Céline
author_facet Bonnet, Anne-Laure
Chaussain, Catherine
Broutin, Isabelle
Rochefort, Gaël Y.
Schrewe, Heinrich
Gaucher, Céline
author_sort Bonnet, Anne-Laure
collection PubMed
description First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. Vasn KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-β and Notch1 pathways offer the most serious assumptions regarding VASN functions. In this review, we will describe current knowledge about this glycoprotein and discuss its implication in various organ pathophysiology.
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spelling pubmed-62881872018-12-18 From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin? Bonnet, Anne-Laure Chaussain, Catherine Broutin, Isabelle Rochefort, Gaël Y. Schrewe, Heinrich Gaucher, Céline Front Med (Lausanne) Medicine First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. Vasn KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-β and Notch1 pathways offer the most serious assumptions regarding VASN functions. In this review, we will describe current knowledge about this glycoprotein and discuss its implication in various organ pathophysiology. Frontiers Media S.A. 2018-12-04 /pmc/articles/PMC6288187/ /pubmed/30564578 http://dx.doi.org/10.3389/fmed.2018.00335 Text en Copyright © 2018 Bonnet, Chaussain, Broutin, Rochefort, Schrewe and Gaucher. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Bonnet, Anne-Laure
Chaussain, Catherine
Broutin, Isabelle
Rochefort, Gaël Y.
Schrewe, Heinrich
Gaucher, Céline
From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?
title From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?
title_full From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?
title_fullStr From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?
title_full_unstemmed From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?
title_short From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?
title_sort from vascular smooth muscle cells to folliculogenesis: what about vasorin?
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288187/
https://www.ncbi.nlm.nih.gov/pubmed/30564578
http://dx.doi.org/10.3389/fmed.2018.00335
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