Tofacitinib for refractory uveitis and scleritis

PURPOSE: To report the successful use of tofacitinib in the treatment of refractory uveitis and scleritis. OBSERVATIONS: Two patients, one with scleritis and another with anterior and intermediate uveitis, presented with refractory disease after failure of multiple steroid-sparing therapies. Treatme...

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Detalles Bibliográficos
Autores principales: Paley, Michael A., Karacal, Humeyra, Rao, P. Kumar, Margolis, Todd P., Miner, Jonathan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288302/
https://www.ncbi.nlm.nih.gov/pubmed/30582071
http://dx.doi.org/10.1016/j.ajoc.2018.12.001
Descripción
Sumario:PURPOSE: To report the successful use of tofacitinib in the treatment of refractory uveitis and scleritis. OBSERVATIONS: Two patients, one with scleritis and another with anterior and intermediate uveitis, presented with refractory disease after failure of multiple steroid-sparing therapies. Treatment with tofacitinib led to durable resolution of uveitis and scleritis. CONCLUSIONS AND IMPORTANCE: Tofacitinib is a potential novel treatment option for refractory, noninfectious inflammatory eye disease.

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