Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy

Current therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we invest...

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Autores principales: Sang, Yimiao, Gu, Xiaohong, Pan, Lulu, Zhang, Chunxiang, Rong, Xing, Wu, Tingting, Xia, Tianhe, Li, Yuechun, Ge, Lisha, Zhang, Yuanhai, Chu, Maoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288359/
https://www.ncbi.nlm.nih.gov/pubmed/30564119
http://dx.doi.org/10.3389/fphar.2018.01384
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author Sang, Yimiao
Gu, Xiaohong
Pan, Lulu
Zhang, Chunxiang
Rong, Xing
Wu, Tingting
Xia, Tianhe
Li, Yuechun
Ge, Lisha
Zhang, Yuanhai
Chu, Maoping
author_facet Sang, Yimiao
Gu, Xiaohong
Pan, Lulu
Zhang, Chunxiang
Rong, Xing
Wu, Tingting
Xia, Tianhe
Li, Yuechun
Ge, Lisha
Zhang, Yuanhai
Chu, Maoping
author_sort Sang, Yimiao
collection PubMed
description Current therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we investigated the protective effect of MLT on viral myocarditis in a mouse model of myocarditis infected with coxsackievirus B3 (CVB3) and explored the probable mechanisms. Mice with CVB3-induced myocarditis displayed inflammatory cell infiltration and interstitial edema. MLT treatment significantly ameliorated the myocardial injuries. In addition, the rate of autophagy changed, although apoptosis was inhibited in mouse hearts following treatment with MLT. These results suggest that MLT has a strong therapeutic effect on acute viral myocarditis, which is associated with changes in autophagy and apoptosis in the heart. Thus, MLT could be a promising novel therapeutic approach against viral myocarditis.
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spelling pubmed-62883592018-12-18 Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy Sang, Yimiao Gu, Xiaohong Pan, Lulu Zhang, Chunxiang Rong, Xing Wu, Tingting Xia, Tianhe Li, Yuechun Ge, Lisha Zhang, Yuanhai Chu, Maoping Front Pharmacol Pharmacology Current therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we investigated the protective effect of MLT on viral myocarditis in a mouse model of myocarditis infected with coxsackievirus B3 (CVB3) and explored the probable mechanisms. Mice with CVB3-induced myocarditis displayed inflammatory cell infiltration and interstitial edema. MLT treatment significantly ameliorated the myocardial injuries. In addition, the rate of autophagy changed, although apoptosis was inhibited in mouse hearts following treatment with MLT. These results suggest that MLT has a strong therapeutic effect on acute viral myocarditis, which is associated with changes in autophagy and apoptosis in the heart. Thus, MLT could be a promising novel therapeutic approach against viral myocarditis. Frontiers Media S.A. 2018-12-04 /pmc/articles/PMC6288359/ /pubmed/30564119 http://dx.doi.org/10.3389/fphar.2018.01384 Text en Copyright © 2018 Sang, Gu, Pan, Zhang, Rong, Wu, Xia, Li, Ge, Zhang and Chu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Sang, Yimiao
Gu, Xiaohong
Pan, Lulu
Zhang, Chunxiang
Rong, Xing
Wu, Tingting
Xia, Tianhe
Li, Yuechun
Ge, Lisha
Zhang, Yuanhai
Chu, Maoping
Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy
title Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy
title_full Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy
title_fullStr Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy
title_full_unstemmed Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy
title_short Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy
title_sort melatonin ameliorates coxsackievirus b3-induced myocarditis by regulating apoptosis and autophagy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288359/
https://www.ncbi.nlm.nih.gov/pubmed/30564119
http://dx.doi.org/10.3389/fphar.2018.01384
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