Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay

We screened 583 chemicals for receptor binding activity to the human estrogen receptor (hER), the Japanese medaka estrogen receptor (medER), and the aryl hydrocarbon receptor (AhR) using the yeast two-hybrid assay. The substances tested included substances that could potentially be produced unintent...

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Autores principales: Shiraishi, Fujio, Kamata, Ryo, Terasaki, Masanori, Takigami, Hidetaka, Imaizumi, Yoshitaka, Yagishita, Mayuko, Nakajima, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Biochemistry, Genetics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288393/
https://www.ncbi.nlm.nih.gov/pubmed/30761335
http://dx.doi.org/10.1016/j.dib.2018.11.071
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author Shiraishi, Fujio
Kamata, Ryo
Terasaki, Masanori
Takigami, Hidetaka
Imaizumi, Yoshitaka
Yagishita, Mayuko
Nakajima, Daisuke
author_facet Shiraishi, Fujio
Kamata, Ryo
Terasaki, Masanori
Takigami, Hidetaka
Imaizumi, Yoshitaka
Yagishita, Mayuko
Nakajima, Daisuke
author_sort Shiraishi, Fujio
collection PubMed
description We screened 583 chemicals for receptor binding activity to the human estrogen receptor (hER), the Japanese medaka estrogen receptor (medER), and the aryl hydrocarbon receptor (AhR) using the yeast two-hybrid assay. The substances tested included substances that could potentially be produced unintentionally by industrial processes, such as halogenated steroids and phenols. Antagonistic effects on hER and the androgen receptor were also screened. The test chemicals were selected for screening on the basis of chemical structure associated with possible estrogen receptor binding activity. The current study presents the report on the screening of 583 chemicals for different kinds of endocrine disrupting activity.
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spelling pubmed-62883932019-02-13 Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay Shiraishi, Fujio Kamata, Ryo Terasaki, Masanori Takigami, Hidetaka Imaizumi, Yoshitaka Yagishita, Mayuko Nakajima, Daisuke Data Brief Biochemistry, Genetics and Molecular Biology We screened 583 chemicals for receptor binding activity to the human estrogen receptor (hER), the Japanese medaka estrogen receptor (medER), and the aryl hydrocarbon receptor (AhR) using the yeast two-hybrid assay. The substances tested included substances that could potentially be produced unintentionally by industrial processes, such as halogenated steroids and phenols. Antagonistic effects on hER and the androgen receptor were also screened. The test chemicals were selected for screening on the basis of chemical structure associated with possible estrogen receptor binding activity. The current study presents the report on the screening of 583 chemicals for different kinds of endocrine disrupting activity. Elsevier 2018-11-23 /pmc/articles/PMC6288393/ /pubmed/30761335 http://dx.doi.org/10.1016/j.dib.2018.11.071 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Shiraishi, Fujio
Kamata, Ryo
Terasaki, Masanori
Takigami, Hidetaka
Imaizumi, Yoshitaka
Yagishita, Mayuko
Nakajima, Daisuke
Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay
title Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay
title_full Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay
title_fullStr Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay
title_full_unstemmed Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay
title_short Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay
title_sort screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288393/
https://www.ncbi.nlm.nih.gov/pubmed/30761335
http://dx.doi.org/10.1016/j.dib.2018.11.071
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