Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity, influencing predisposition to immune mediated disease, and affecting hematopoietic stem cell transplantation (HSCT) outcome. Owing to the complexity of the KIR locus, with extensive gene copy number varia...

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Detalles Bibliográficos
Autores principales: Wagner, Ines, Schefzyk, Daniel, Pruschke, Jens, Schöfl, Gerhard, Schöne, Bianca, Gruber, Nicole, Lang, Kathrin, Hofmann, Jan, Gnahm, Christine, Heyn, Bianca, Marin, Wesley M., Dandekar, Ravi, Hollenbach, Jill A., Schetelig, Johannes, Pingel, Julia, Norman, Paul J., Sauter, Jürgen, Schmidt, Alexander H., Lange, Vinzenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288436/
https://www.ncbi.nlm.nih.gov/pubmed/30564239
http://dx.doi.org/10.3389/fimmu.2018.02843

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