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Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD

Soluble molecules of the major histocompatibility complex play an important role in the development of various immune-mediated diseases. However, there is not much information on the participation of these proteins in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of our w...

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Autores principales: Kubysheva, Nailya, Soodaeva, Svetlana, Novikov, Viktor, Eliseeva, Tatyana, Li, Timur, Klimanov, Igor, Kuzmina, Elena, Baez-Medina, Héctor, Solovyev, Valery, Ovsyannikov, Dmitry Yu., Batyrshin, Ildar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288564/
https://www.ncbi.nlm.nih.gov/pubmed/30598706
http://dx.doi.org/10.1155/2018/3614341
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author Kubysheva, Nailya
Soodaeva, Svetlana
Novikov, Viktor
Eliseeva, Tatyana
Li, Timur
Klimanov, Igor
Kuzmina, Elena
Baez-Medina, Héctor
Solovyev, Valery
Ovsyannikov, Dmitry Yu.
Batyrshin, Ildar
author_facet Kubysheva, Nailya
Soodaeva, Svetlana
Novikov, Viktor
Eliseeva, Tatyana
Li, Timur
Klimanov, Igor
Kuzmina, Elena
Baez-Medina, Héctor
Solovyev, Valery
Ovsyannikov, Dmitry Yu.
Batyrshin, Ildar
author_sort Kubysheva, Nailya
collection PubMed
description Soluble molecules of the major histocompatibility complex play an important role in the development of various immune-mediated diseases. However, there is not much information on the participation of these proteins in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of our work was to determine the content of soluble molecules of the major histocompatibility complex of classes I and II (sHLA-I and sHLA-II) in the exhaled breath condensate (EBC) and in the blood serum in patients with moderate to severe COPD during the exacerbation and stable phase. We investigated 105 patients (male) with COPD aged 46–67 and 21 healthy nonsmoking volunteers (male) comparable in age. The content of sHLA-I and sHLA-II molecules was studied using ELISA. We found an increase in the level of sHLA-I and sHLA-II molecules in EBC, as well as an enhancement in the serum content of sHLA-II in all the examined COPD patients compared to healthy nonsmoking volunteers. The revealed negative correlation between the serum concentration of sHLA-II and values of FEV(1) and FEV(1)/FVC in all examined patients with COPD gives a possibility to consider the content of these proteins as an additional systemic marker of disease severity. The maximum endobronchial and serum concentrations of sHLA-I and sHLA-II were detected in patients with severe COPD during the exacerbation. The negative associations between the content of these molecules in EBC and serum and the parameters of lung function in patients with severe COPD were established. These findings suggest a pathogenetic role of sHLA-I and sHLA-II molecules in the mechanisms of the development and progression of local and systemic inflammation in COPD.
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spelling pubmed-62885642018-12-31 Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD Kubysheva, Nailya Soodaeva, Svetlana Novikov, Viktor Eliseeva, Tatyana Li, Timur Klimanov, Igor Kuzmina, Elena Baez-Medina, Héctor Solovyev, Valery Ovsyannikov, Dmitry Yu. Batyrshin, Ildar Dis Markers Research Article Soluble molecules of the major histocompatibility complex play an important role in the development of various immune-mediated diseases. However, there is not much information on the participation of these proteins in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of our work was to determine the content of soluble molecules of the major histocompatibility complex of classes I and II (sHLA-I and sHLA-II) in the exhaled breath condensate (EBC) and in the blood serum in patients with moderate to severe COPD during the exacerbation and stable phase. We investigated 105 patients (male) with COPD aged 46–67 and 21 healthy nonsmoking volunteers (male) comparable in age. The content of sHLA-I and sHLA-II molecules was studied using ELISA. We found an increase in the level of sHLA-I and sHLA-II molecules in EBC, as well as an enhancement in the serum content of sHLA-II in all the examined COPD patients compared to healthy nonsmoking volunteers. The revealed negative correlation between the serum concentration of sHLA-II and values of FEV(1) and FEV(1)/FVC in all examined patients with COPD gives a possibility to consider the content of these proteins as an additional systemic marker of disease severity. The maximum endobronchial and serum concentrations of sHLA-I and sHLA-II were detected in patients with severe COPD during the exacerbation. The negative associations between the content of these molecules in EBC and serum and the parameters of lung function in patients with severe COPD were established. These findings suggest a pathogenetic role of sHLA-I and sHLA-II molecules in the mechanisms of the development and progression of local and systemic inflammation in COPD. Hindawi 2018-11-27 /pmc/articles/PMC6288564/ /pubmed/30598706 http://dx.doi.org/10.1155/2018/3614341 Text en Copyright © 2018 Nailya Kubysheva et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kubysheva, Nailya
Soodaeva, Svetlana
Novikov, Viktor
Eliseeva, Tatyana
Li, Timur
Klimanov, Igor
Kuzmina, Elena
Baez-Medina, Héctor
Solovyev, Valery
Ovsyannikov, Dmitry Yu.
Batyrshin, Ildar
Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD
title Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD
title_full Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD
title_fullStr Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD
title_full_unstemmed Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD
title_short Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD
title_sort soluble hla-i and hla-ii molecules are potential prognostic markers of progression of systemic and local inflammation in patients with copd
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288564/
https://www.ncbi.nlm.nih.gov/pubmed/30598706
http://dx.doi.org/10.1155/2018/3614341
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