N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity

[Image: see text] Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbenes derived from guanosine are synthesized via oxidative addition, followed by protonation in the presence of acid. Cytotoxicity of the compounds is evaluated in several cell lines. Compounds 2a, 2b, and 3a are se...

Descripción completa

Detalles Bibliográficos
Autores principales: Leitão, Maria Inês P. S., Herrera, Federico, Petronilho, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288774/
https://www.ncbi.nlm.nih.gov/pubmed/30556009
http://dx.doi.org/10.1021/acsomega.8b02387
_version_ 1783379856347627520
author Leitão, Maria Inês P. S.
Herrera, Federico
Petronilho, Ana
author_facet Leitão, Maria Inês P. S.
Herrera, Federico
Petronilho, Ana
author_sort Leitão, Maria Inês P. S.
collection PubMed
description [Image: see text] Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbenes derived from guanosine are synthesized via oxidative addition, followed by protonation in the presence of acid. Cytotoxicity of the compounds is evaluated in several cell lines. Compounds 2a, 2b, and 3a are selective for glioblastoma U251 cells and are nontoxic toward healthy human embryonic kidney (HEK293) cells.
format Online
Article
Text
id pubmed-6288774
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-62887742018-12-12 N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity Leitão, Maria Inês P. S. Herrera, Federico Petronilho, Ana ACS Omega [Image: see text] Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbenes derived from guanosine are synthesized via oxidative addition, followed by protonation in the presence of acid. Cytotoxicity of the compounds is evaluated in several cell lines. Compounds 2a, 2b, and 3a are selective for glioblastoma U251 cells and are nontoxic toward healthy human embryonic kidney (HEK293) cells. American Chemical Society 2018-11-16 /pmc/articles/PMC6288774/ /pubmed/30556009 http://dx.doi.org/10.1021/acsomega.8b02387 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Leitão, Maria Inês P. S.
Herrera, Federico
Petronilho, Ana
N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity
title N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity
title_full N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity
title_fullStr N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity
title_full_unstemmed N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity
title_short N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity
title_sort n-heterocyclic carbenes derived from guanosine: synthesis and evidences of their antiproliferative activity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288774/
https://www.ncbi.nlm.nih.gov/pubmed/30556009
http://dx.doi.org/10.1021/acsomega.8b02387
work_keys_str_mv AT leitaomariainesps nheterocycliccarbenesderivedfromguanosinesynthesisandevidencesoftheirantiproliferativeactivity
AT herrerafederico nheterocycliccarbenesderivedfromguanosinesynthesisandevidencesoftheirantiproliferativeactivity
AT petronilhoana nheterocycliccarbenesderivedfromguanosinesynthesisandevidencesoftheirantiproliferativeactivity

Ejemplares similares