Antibiotic-Induced Cell Chaining Triggers Pneumococcal Competence by Reshaping Quorum Sensing to Autocrine-Like Signaling

Streptococcus pneumoniae can acquire antibiotic resistance by activation of competence and subsequent DNA uptake. Here, we demonstrate that aztreonam (ATM) and clavulanic acid (CLA) promote competence. We show that both compounds induce cell chain formation by targeting the d,d-carboxypeptidase PBP3...

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Detalles Bibliográficos
Autores principales: Domenech, Arnau, Slager, Jelle, Veening, Jan-Willem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289044/
https://www.ncbi.nlm.nih.gov/pubmed/30485808
http://dx.doi.org/10.1016/j.celrep.2018.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289044/
https://www.ncbi.nlm.nih.gov/pubmed/30485808
http://dx.doi.org/10.1016/j.celrep.2018.11.007

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