Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer

Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and toxicity phenoty...

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Autores principales: Wang, Lei-Yun, Cui, Jia-Jia, Liu, Jun-Yan, Guo, Ao-Xiang, Zhao, Zhen-Yu, Liu, Ying-Zi, Wu, Ji-Chu, Li, Min, Hu, Cheng-Ping, Gao, Yang, Zhou, Hong-Hao, Yin, Ji-Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
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Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289114/
https://www.ncbi.nlm.nih.gov/pubmed/30531820
http://dx.doi.org/10.1038/sdata.2018.284
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author Wang, Lei-Yun
Cui, Jia-Jia
Liu, Jun-Yan
Guo, Ao-Xiang
Zhao, Zhen-Yu
Liu, Ying-Zi
Wu, Ji-Chu
Li, Min
Hu, Cheng-Ping
Gao, Yang
Zhou, Hong-Hao
Yin, Ji-Ye
author_facet Wang, Lei-Yun
Cui, Jia-Jia
Liu, Jun-Yan
Guo, Ao-Xiang
Zhao, Zhen-Yu
Liu, Ying-Zi
Wu, Ji-Chu
Li, Min
Hu, Cheng-Ping
Gao, Yang
Zhou, Hong-Hao
Yin, Ji-Ye
author_sort Wang, Lei-Yun
collection PubMed
description Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and toxicity phenotypes. We genotyped 504 SNPs in a total of 490 Chinese non-small cell lung cancer (NSCLC) patients, and the correlation of GXG and GXE interactions with platinum-based chemotherapeutic efficacy and safety were analyzed. In this data descriptor, we shared our data set which could help others to reuse them. All kinds of file types needed for GXG and GXE analysis were supplied. The process of genotyping and data analysis was also introduced step by step.
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spelling pubmed-62891142018-12-12 Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer Wang, Lei-Yun Cui, Jia-Jia Liu, Jun-Yan Guo, Ao-Xiang Zhao, Zhen-Yu Liu, Ying-Zi Wu, Ji-Chu Li, Min Hu, Cheng-Ping Gao, Yang Zhou, Hong-Hao Yin, Ji-Ye Sci Data Data Descriptor Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and toxicity phenotypes. We genotyped 504 SNPs in a total of 490 Chinese non-small cell lung cancer (NSCLC) patients, and the correlation of GXG and GXE interactions with platinum-based chemotherapeutic efficacy and safety were analyzed. In this data descriptor, we shared our data set which could help others to reuse them. All kinds of file types needed for GXG and GXE analysis were supplied. The process of genotyping and data analysis was also introduced step by step. Nature Publishing Group 2018-12-11 /pmc/articles/PMC6289114/ /pubmed/30531820 http://dx.doi.org/10.1038/sdata.2018.284 Text en Copyright © 2018, The Author(s) http://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.
spellingShingle Data Descriptor
Wang, Lei-Yun
Cui, Jia-Jia
Liu, Jun-Yan
Guo, Ao-Xiang
Zhao, Zhen-Yu
Liu, Ying-Zi
Wu, Ji-Chu
Li, Min
Hu, Cheng-Ping
Gao, Yang
Zhou, Hong-Hao
Yin, Ji-Ye
Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer
title Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer
title_full Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer
title_fullStr Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer
title_full_unstemmed Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer
title_short Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer
title_sort gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289114/
https://www.ncbi.nlm.nih.gov/pubmed/30531820
http://dx.doi.org/10.1038/sdata.2018.284
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