Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU,...

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Autores principales: Zhou, Shuqin, Skaar, Debra J., Jacobson, Pamala A., Huang, R. Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289166/
https://www.ncbi.nlm.nih.gov/pubmed/30564130
http://dx.doi.org/10.3389/fphar.2018.01436
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author Zhou, Shuqin
Skaar, Debra J.
Jacobson, Pamala A.
Huang, R. Stephanie
author_facet Zhou, Shuqin
Skaar, Debra J.
Jacobson, Pamala A.
Huang, R. Stephanie
author_sort Zhou, Shuqin
collection PubMed
description In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.
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spelling pubmed-62891662018-12-18 Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit Zhou, Shuqin Skaar, Debra J. Jacobson, Pamala A. Huang, R. Stephanie Front Pharmacol Pharmacology In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU. Frontiers Media S.A. 2018-12-04 /pmc/articles/PMC6289166/ /pubmed/30564130 http://dx.doi.org/10.3389/fphar.2018.01436 Text en Copyright © 2018 Zhou, Skaar, Jacobson and Huang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhou, Shuqin
Skaar, Debra J.
Jacobson, Pamala A.
Huang, R. Stephanie
Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit
title Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit
title_full Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit
title_fullStr Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit
title_full_unstemmed Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit
title_short Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit
title_sort pharmacogenomics of medications commonly used in the intensive care unit
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289166/
https://www.ncbi.nlm.nih.gov/pubmed/30564130
http://dx.doi.org/10.3389/fphar.2018.01436
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