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Functional protein nanostructures: a chemical toolbox
Nature has evolved an optimal synthetic factory in the form of translational and posttranslational processes by which millions of proteins with defined primary sequences and 3D structures can be built. Nature's toolkit gives rise to protein building blocks, which dictates their spatial arrangem...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289173/ https://www.ncbi.nlm.nih.gov/pubmed/30452046 http://dx.doi.org/10.1039/c8cs00590g |
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author | Kuan, Seah Ling Bergamini, Fernando R. G. Weil, Tanja |
author_facet | Kuan, Seah Ling Bergamini, Fernando R. G. Weil, Tanja |
author_sort | Kuan, Seah Ling |
collection | PubMed |
description | Nature has evolved an optimal synthetic factory in the form of translational and posttranslational processes by which millions of proteins with defined primary sequences and 3D structures can be built. Nature's toolkit gives rise to protein building blocks, which dictates their spatial arrangement to form functional protein nanostructures that serve a myriad of functions in cells, ranging from biocatalysis, formation of structural networks, and regulation of biochemical processes, to sensing. With the advent of chemical tools for site-selective protein modifications and recombinant engineering, there is a rapid development to develop and apply synthetic methods for creating structurally defined, functional protein nanostructures for a broad range of applications in the fields of catalysis, materials and biomedical sciences. In this review, design principles and structural features for achieving and characterizing functional protein nanostructures by synthetic approaches are summarized. The synthetic customization of protein building blocks, the design and introduction of recognition units and linkers and subsequent assembly into structurally defined protein architectures are discussed herein. Key examples of these supramolecular protein nanostructures, their unique functions and resultant impact for biomedical applications are highlighted. |
format | Online Article Text |
id | pubmed-6289173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-62891732019-01-09 Functional protein nanostructures: a chemical toolbox Kuan, Seah Ling Bergamini, Fernando R. G. Weil, Tanja Chem Soc Rev Chemistry Nature has evolved an optimal synthetic factory in the form of translational and posttranslational processes by which millions of proteins with defined primary sequences and 3D structures can be built. Nature's toolkit gives rise to protein building blocks, which dictates their spatial arrangement to form functional protein nanostructures that serve a myriad of functions in cells, ranging from biocatalysis, formation of structural networks, and regulation of biochemical processes, to sensing. With the advent of chemical tools for site-selective protein modifications and recombinant engineering, there is a rapid development to develop and apply synthetic methods for creating structurally defined, functional protein nanostructures for a broad range of applications in the fields of catalysis, materials and biomedical sciences. In this review, design principles and structural features for achieving and characterizing functional protein nanostructures by synthetic approaches are summarized. The synthetic customization of protein building blocks, the design and introduction of recognition units and linkers and subsequent assembly into structurally defined protein architectures are discussed herein. Key examples of these supramolecular protein nanostructures, their unique functions and resultant impact for biomedical applications are highlighted. Royal Society of Chemistry 2018-12-21 2018-11-19 /pmc/articles/PMC6289173/ /pubmed/30452046 http://dx.doi.org/10.1039/c8cs00590g Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
spellingShingle | Chemistry Kuan, Seah Ling Bergamini, Fernando R. G. Weil, Tanja Functional protein nanostructures: a chemical toolbox |
title | Functional protein nanostructures: a chemical toolbox |
title_full | Functional protein nanostructures: a chemical toolbox |
title_fullStr | Functional protein nanostructures: a chemical toolbox |
title_full_unstemmed | Functional protein nanostructures: a chemical toolbox |
title_short | Functional protein nanostructures: a chemical toolbox |
title_sort | functional protein nanostructures: a chemical toolbox |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289173/ https://www.ncbi.nlm.nih.gov/pubmed/30452046 http://dx.doi.org/10.1039/c8cs00590g |
work_keys_str_mv | AT kuanseahling functionalproteinnanostructuresachemicaltoolbox AT bergaminifernandorg functionalproteinnanostructuresachemicaltoolbox AT weiltanja functionalproteinnanostructuresachemicaltoolbox |