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Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study

CONTEXT: Tehran Lipid and Glucose Study (TLGS), a longitudinal family based cohort study, is the oldest and largest longitudinal family based study in Iran, aimed at investigating effects of environmental, social and biological factors on the health of Tehranians over time. Considering the importanc...

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Autores principales: Daneshpour, Maryam S, Hedayati, Mehdi, Sedaghati-Khayat, Bahareh, Guity, Kamran, Zarkesh, Maryam, Akbarzadeh, Mahdi, Javanrooh, Niloofar, Zadeh-Vakili, Azita, Azizi, Fereidoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289296/
https://www.ncbi.nlm.nih.gov/pubmed/30584432
http://dx.doi.org/10.5812/ijem.84744
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author Daneshpour, Maryam S
Hedayati, Mehdi
Sedaghati-Khayat, Bahareh
Guity, Kamran
Zarkesh, Maryam
Akbarzadeh, Mahdi
Javanrooh, Niloofar
Zadeh-Vakili, Azita
Azizi, Fereidoun
author_facet Daneshpour, Maryam S
Hedayati, Mehdi
Sedaghati-Khayat, Bahareh
Guity, Kamran
Zarkesh, Maryam
Akbarzadeh, Mahdi
Javanrooh, Niloofar
Zadeh-Vakili, Azita
Azizi, Fereidoun
author_sort Daneshpour, Maryam S
collection PubMed
description CONTEXT: Tehran Lipid and Glucose Study (TLGS), a longitudinal family based cohort study, is the oldest and largest longitudinal family based study in Iran, aimed at investigating effects of environmental, social and biological factors on the health of Tehranians over time. Considering the importance of genetic studies in this aspect, here we present a summary of the important genetic findings, and the potentiality of their contributions to future related projects. EVIDENCE ACQUISITION: For all related studies during the past 20 years the search sources were all prominent search engines such as PubMed, Scopus, and Google Scholar with the most proper Medical Subject Headings (MeSH). RESULTS: This review summarizes associations of 6 binary phenotypes and 17 quantitative traits with genetic markers in 26 genes. Of the 47 genetic markers, studied most were related to cardio metabolic risk factors. Results of heritability and linkage analysis were also collected and the highest heritability was found to be related to HDL-C (0.5). CONCLUSION: Considering the opportunity provided by large-scale cohort studies to investigate molecular effects of genetic variants on causality and different omics’ data, genetic studies conducted on TLGS population have had a remarkable success in identifying genetic variants that facilitating a unique genetic database on Iranian populations. The results of genome wide association studies in this population are currently facilitating investigations to define the Iranian genetic differences with other population.
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spelling pubmed-62892962018-12-24 Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study Daneshpour, Maryam S Hedayati, Mehdi Sedaghati-Khayat, Bahareh Guity, Kamran Zarkesh, Maryam Akbarzadeh, Mahdi Javanrooh, Niloofar Zadeh-Vakili, Azita Azizi, Fereidoun Int J Endocrinol Metab Review Article CONTEXT: Tehran Lipid and Glucose Study (TLGS), a longitudinal family based cohort study, is the oldest and largest longitudinal family based study in Iran, aimed at investigating effects of environmental, social and biological factors on the health of Tehranians over time. Considering the importance of genetic studies in this aspect, here we present a summary of the important genetic findings, and the potentiality of their contributions to future related projects. EVIDENCE ACQUISITION: For all related studies during the past 20 years the search sources were all prominent search engines such as PubMed, Scopus, and Google Scholar with the most proper Medical Subject Headings (MeSH). RESULTS: This review summarizes associations of 6 binary phenotypes and 17 quantitative traits with genetic markers in 26 genes. Of the 47 genetic markers, studied most were related to cardio metabolic risk factors. Results of heritability and linkage analysis were also collected and the highest heritability was found to be related to HDL-C (0.5). CONCLUSION: Considering the opportunity provided by large-scale cohort studies to investigate molecular effects of genetic variants on causality and different omics’ data, genetic studies conducted on TLGS population have had a remarkable success in identifying genetic variants that facilitating a unique genetic database on Iranian populations. The results of genome wide association studies in this population are currently facilitating investigations to define the Iranian genetic differences with other population. Kowsar 2018-10-27 /pmc/articles/PMC6289296/ /pubmed/30584432 http://dx.doi.org/10.5812/ijem.84744 Text en Copyright © 2018, International Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Review Article
Daneshpour, Maryam S
Hedayati, Mehdi
Sedaghati-Khayat, Bahareh
Guity, Kamran
Zarkesh, Maryam
Akbarzadeh, Mahdi
Javanrooh, Niloofar
Zadeh-Vakili, Azita
Azizi, Fereidoun
Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study
title Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study
title_full Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study
title_fullStr Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study
title_full_unstemmed Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study
title_short Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study
title_sort genetic identification for non-communicable disease: findings from 20 years of the tehran lipid and glucose study
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289296/
https://www.ncbi.nlm.nih.gov/pubmed/30584432
http://dx.doi.org/10.5812/ijem.84744
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