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Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis

BACKGROUND: This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME). METHODS: This retrospective, interventional study included a total 131 treatment-naïve Behçet patients with varying deg...

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Autores principales: Kang, Hae Min, Koh, Hyoung Jun, Lee, Sung Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289405/
https://www.ncbi.nlm.nih.gov/pubmed/30533014
http://dx.doi.org/10.1371/journal.pone.0208254
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author Kang, Hae Min
Koh, Hyoung Jun
Lee, Sung Chul
author_facet Kang, Hae Min
Koh, Hyoung Jun
Lee, Sung Chul
author_sort Kang, Hae Min
collection PubMed
description BACKGROUND: This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME). METHODS: This retrospective, interventional study included a total 131 treatment-naïve Behçet patients with varying degree of uveitis in the absence of ME. The mean CMT and MV were obtained by spectral domain optical coherence tomography (SD ODT). The patients were classified according to the anatomical classification of Behçet uveitis. The main outcome measure was comparison of mean CMT and MV with the types of Behçet uveitis. RESULTS: Sixty patients (45.8%) with no uveitis, 41 patients (31.3%) with anterior uveitis, 18 patients (13.7%) with posterior uveitis, and 12 patients (9.2%) with panuveitis. The mean CMT were 261.6±22.2 μm in no uveitis, 268.1±17.8 μm in anterior uveitis, 306.4±32.9 μm in posterior uveitis, and 300.4±44.0 μm in panuveitis (P < 0.001). The mean MV was 8.7±0.3 mm(3) in those without uveitis, 8.8±0.3 mm(3) in anterior uveitis, 9.9±1.1 mm(3) in those with posterior uveitis, and 9.7±0.4 mm(3) in panuveitis (P < 0.001). Types of Behçet uveitis was the only significant factor correlated with the mean CMT (B = 18.170, β = 0.408, P < 0.001) and the mean MV (B = 0.328, β = 0.652, P < 0.001). CONCLUSIONS: The mean CMT and MV were significantly thicker in the Behçet uveitis with posterior involvement. SD OCT can be used for an adjunctive tool for screening Behçet uveitis, especially for the presence of posterior involvement.
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spelling pubmed-62894052018-12-28 Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis Kang, Hae Min Koh, Hyoung Jun Lee, Sung Chul PLoS One Research Article BACKGROUND: This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME). METHODS: This retrospective, interventional study included a total 131 treatment-naïve Behçet patients with varying degree of uveitis in the absence of ME. The mean CMT and MV were obtained by spectral domain optical coherence tomography (SD ODT). The patients were classified according to the anatomical classification of Behçet uveitis. The main outcome measure was comparison of mean CMT and MV with the types of Behçet uveitis. RESULTS: Sixty patients (45.8%) with no uveitis, 41 patients (31.3%) with anterior uveitis, 18 patients (13.7%) with posterior uveitis, and 12 patients (9.2%) with panuveitis. The mean CMT were 261.6±22.2 μm in no uveitis, 268.1±17.8 μm in anterior uveitis, 306.4±32.9 μm in posterior uveitis, and 300.4±44.0 μm in panuveitis (P < 0.001). The mean MV was 8.7±0.3 mm(3) in those without uveitis, 8.8±0.3 mm(3) in anterior uveitis, 9.9±1.1 mm(3) in those with posterior uveitis, and 9.7±0.4 mm(3) in panuveitis (P < 0.001). Types of Behçet uveitis was the only significant factor correlated with the mean CMT (B = 18.170, β = 0.408, P < 0.001) and the mean MV (B = 0.328, β = 0.652, P < 0.001). CONCLUSIONS: The mean CMT and MV were significantly thicker in the Behçet uveitis with posterior involvement. SD OCT can be used for an adjunctive tool for screening Behçet uveitis, especially for the presence of posterior involvement. Public Library of Science 2018-12-11 /pmc/articles/PMC6289405/ /pubmed/30533014 http://dx.doi.org/10.1371/journal.pone.0208254 Text en © 2018 Kang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kang, Hae Min
Koh, Hyoung Jun
Lee, Sung Chul
Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis
title Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis
title_full Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis
title_fullStr Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis
title_full_unstemmed Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis
title_short Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis
title_sort spectral domain optical coherence tomography as an adjunctive tool for screening behçet uveitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289405/
https://www.ncbi.nlm.nih.gov/pubmed/30533014
http://dx.doi.org/10.1371/journal.pone.0208254
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