Cargando…

Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study

Fatty acids in adipose tissue share dietary sources and metabolic pathways and therefore occur in patterns. The aim of the present study was to investigate the association between adipose tissue fatty acid patterns identified by the data-driven dimension-reducing method treelet transform and the ris...

Descripción completa

Detalles Bibliográficos
Autores principales: Dinesen, Pia Thisted, Rix, Thomas Andersen, Joensen, Albert Marni, Dahm, Christina Cathrine, Lundbye-Christensen, Søren, Schmidt, Erik Berg, Overvad, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289440/
https://www.ncbi.nlm.nih.gov/pubmed/30533060
http://dx.doi.org/10.1371/journal.pone.0208833
_version_ 1783379958794551296
author Dinesen, Pia Thisted
Rix, Thomas Andersen
Joensen, Albert Marni
Dahm, Christina Cathrine
Lundbye-Christensen, Søren
Schmidt, Erik Berg
Overvad, Kim
author_facet Dinesen, Pia Thisted
Rix, Thomas Andersen
Joensen, Albert Marni
Dahm, Christina Cathrine
Lundbye-Christensen, Søren
Schmidt, Erik Berg
Overvad, Kim
author_sort Dinesen, Pia Thisted
collection PubMed
description Fatty acids in adipose tissue share dietary sources and metabolic pathways and therefore occur in patterns. The aim of the present study was to investigate the association between adipose tissue fatty acid patterns identified by the data-driven dimension-reducing method treelet transform and the risk of atrial fibrillation. A total of 57,053 Danish men and women aged 50–64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline. During a median follow-up of 14.6 years, a total of 4,710 participants developed atrial fibrillation or atrial flutter. Adipose tissue biopsies were analysed for fatty acid content by gas chromatography for all cases of atrial fibrillation and for a randomly drawn subcohort (n = 3,500) representative for the entire cohort. Hazard ratios with 95% confidence intervals for atrial fibrillation according to quintiles of factor scores were determined by weighted Cox proportional hazards regression analyses for men and women separately. From the 32 fatty acids measured, 7 major factors/patterns of fatty acids were identified using treelet transform. We found that a pattern consisting of n-6 polyunsaturated fatty acids (PUFA) (except linoleic acid) was associated with a lower hazard of atrial fibrillation. Patterns consisting of marine n-3 PUFA and containing n-9 fatty acids were associated with a lower hazard of atrial fibrillation in women. In conclusion, patterns of fatty acids in adipose tissue identified by treelet transform may be differentially associated with the risk of atrial fibrillation.
format Online
Article
Text
id pubmed-6289440
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-62894402018-12-28 Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study Dinesen, Pia Thisted Rix, Thomas Andersen Joensen, Albert Marni Dahm, Christina Cathrine Lundbye-Christensen, Søren Schmidt, Erik Berg Overvad, Kim PLoS One Research Article Fatty acids in adipose tissue share dietary sources and metabolic pathways and therefore occur in patterns. The aim of the present study was to investigate the association between adipose tissue fatty acid patterns identified by the data-driven dimension-reducing method treelet transform and the risk of atrial fibrillation. A total of 57,053 Danish men and women aged 50–64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline. During a median follow-up of 14.6 years, a total of 4,710 participants developed atrial fibrillation or atrial flutter. Adipose tissue biopsies were analysed for fatty acid content by gas chromatography for all cases of atrial fibrillation and for a randomly drawn subcohort (n = 3,500) representative for the entire cohort. Hazard ratios with 95% confidence intervals for atrial fibrillation according to quintiles of factor scores were determined by weighted Cox proportional hazards regression analyses for men and women separately. From the 32 fatty acids measured, 7 major factors/patterns of fatty acids were identified using treelet transform. We found that a pattern consisting of n-6 polyunsaturated fatty acids (PUFA) (except linoleic acid) was associated with a lower hazard of atrial fibrillation. Patterns consisting of marine n-3 PUFA and containing n-9 fatty acids were associated with a lower hazard of atrial fibrillation in women. In conclusion, patterns of fatty acids in adipose tissue identified by treelet transform may be differentially associated with the risk of atrial fibrillation. Public Library of Science 2018-12-11 /pmc/articles/PMC6289440/ /pubmed/30533060 http://dx.doi.org/10.1371/journal.pone.0208833 Text en © 2018 Dinesen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Dinesen, Pia Thisted
Rix, Thomas Andersen
Joensen, Albert Marni
Dahm, Christina Cathrine
Lundbye-Christensen, Søren
Schmidt, Erik Berg
Overvad, Kim
Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study
title Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study
title_full Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study
title_fullStr Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study
title_full_unstemmed Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study
title_short Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study
title_sort patterns of adipose tissue fatty acids and the risk of atrial fibrillation: a case-cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289440/
https://www.ncbi.nlm.nih.gov/pubmed/30533060
http://dx.doi.org/10.1371/journal.pone.0208833
work_keys_str_mv AT dinesenpiathisted patternsofadiposetissuefattyacidsandtheriskofatrialfibrillationacasecohortstudy
AT rixthomasandersen patternsofadiposetissuefattyacidsandtheriskofatrialfibrillationacasecohortstudy
AT joensenalbertmarni patternsofadiposetissuefattyacidsandtheriskofatrialfibrillationacasecohortstudy
AT dahmchristinacathrine patternsofadiposetissuefattyacidsandtheriskofatrialfibrillationacasecohortstudy
AT lundbyechristensensøren patternsofadiposetissuefattyacidsandtheriskofatrialfibrillationacasecohortstudy
AT schmidterikberg patternsofadiposetissuefattyacidsandtheriskofatrialfibrillationacasecohortstudy
AT overvadkim patternsofadiposetissuefattyacidsandtheriskofatrialfibrillationacasecohortstudy