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Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study
Fatty acids in adipose tissue share dietary sources and metabolic pathways and therefore occur in patterns. The aim of the present study was to investigate the association between adipose tissue fatty acid patterns identified by the data-driven dimension-reducing method treelet transform and the ris...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289440/ https://www.ncbi.nlm.nih.gov/pubmed/30533060 http://dx.doi.org/10.1371/journal.pone.0208833 |
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author | Dinesen, Pia Thisted Rix, Thomas Andersen Joensen, Albert Marni Dahm, Christina Cathrine Lundbye-Christensen, Søren Schmidt, Erik Berg Overvad, Kim |
author_facet | Dinesen, Pia Thisted Rix, Thomas Andersen Joensen, Albert Marni Dahm, Christina Cathrine Lundbye-Christensen, Søren Schmidt, Erik Berg Overvad, Kim |
author_sort | Dinesen, Pia Thisted |
collection | PubMed |
description | Fatty acids in adipose tissue share dietary sources and metabolic pathways and therefore occur in patterns. The aim of the present study was to investigate the association between adipose tissue fatty acid patterns identified by the data-driven dimension-reducing method treelet transform and the risk of atrial fibrillation. A total of 57,053 Danish men and women aged 50–64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline. During a median follow-up of 14.6 years, a total of 4,710 participants developed atrial fibrillation or atrial flutter. Adipose tissue biopsies were analysed for fatty acid content by gas chromatography for all cases of atrial fibrillation and for a randomly drawn subcohort (n = 3,500) representative for the entire cohort. Hazard ratios with 95% confidence intervals for atrial fibrillation according to quintiles of factor scores were determined by weighted Cox proportional hazards regression analyses for men and women separately. From the 32 fatty acids measured, 7 major factors/patterns of fatty acids were identified using treelet transform. We found that a pattern consisting of n-6 polyunsaturated fatty acids (PUFA) (except linoleic acid) was associated with a lower hazard of atrial fibrillation. Patterns consisting of marine n-3 PUFA and containing n-9 fatty acids were associated with a lower hazard of atrial fibrillation in women. In conclusion, patterns of fatty acids in adipose tissue identified by treelet transform may be differentially associated with the risk of atrial fibrillation. |
format | Online Article Text |
id | pubmed-6289440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62894402018-12-28 Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study Dinesen, Pia Thisted Rix, Thomas Andersen Joensen, Albert Marni Dahm, Christina Cathrine Lundbye-Christensen, Søren Schmidt, Erik Berg Overvad, Kim PLoS One Research Article Fatty acids in adipose tissue share dietary sources and metabolic pathways and therefore occur in patterns. The aim of the present study was to investigate the association between adipose tissue fatty acid patterns identified by the data-driven dimension-reducing method treelet transform and the risk of atrial fibrillation. A total of 57,053 Danish men and women aged 50–64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline. During a median follow-up of 14.6 years, a total of 4,710 participants developed atrial fibrillation or atrial flutter. Adipose tissue biopsies were analysed for fatty acid content by gas chromatography for all cases of atrial fibrillation and for a randomly drawn subcohort (n = 3,500) representative for the entire cohort. Hazard ratios with 95% confidence intervals for atrial fibrillation according to quintiles of factor scores were determined by weighted Cox proportional hazards regression analyses for men and women separately. From the 32 fatty acids measured, 7 major factors/patterns of fatty acids were identified using treelet transform. We found that a pattern consisting of n-6 polyunsaturated fatty acids (PUFA) (except linoleic acid) was associated with a lower hazard of atrial fibrillation. Patterns consisting of marine n-3 PUFA and containing n-9 fatty acids were associated with a lower hazard of atrial fibrillation in women. In conclusion, patterns of fatty acids in adipose tissue identified by treelet transform may be differentially associated with the risk of atrial fibrillation. Public Library of Science 2018-12-11 /pmc/articles/PMC6289440/ /pubmed/30533060 http://dx.doi.org/10.1371/journal.pone.0208833 Text en © 2018 Dinesen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Dinesen, Pia Thisted Rix, Thomas Andersen Joensen, Albert Marni Dahm, Christina Cathrine Lundbye-Christensen, Søren Schmidt, Erik Berg Overvad, Kim Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study |
title | Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study |
title_full | Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study |
title_fullStr | Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study |
title_full_unstemmed | Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study |
title_short | Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study |
title_sort | patterns of adipose tissue fatty acids and the risk of atrial fibrillation: a case-cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289440/ https://www.ncbi.nlm.nih.gov/pubmed/30533060 http://dx.doi.org/10.1371/journal.pone.0208833 |
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